Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
Peer-reviewed industrial hemp research by Jinlong Zhang; Jie Yan; Shuyue Li; Qianqian Chen; Lin Jiang; Yilin Peng; Yuhang Liu; Binbin Wang; Xinrong Wei; Chen Sun published in Heliyon (2024).
Rome IV diagnostic criteria 1 for IBS* Recurrent abdominal pain, on average: At least 1 day per week in the last 3 months Associated with 2 or more of the following: 4. Related to defecation 5. Associated with a change in frequency of stool 6. Associated with a change in form (appearance of stool) *Onset of symptoms at least 6 months prior to diagnosis Box 1.3 Rome IV diagnostic criteria for IBS, published in 2016.
Maternal separation (MS) represents a profound early life stressor with enduring impacts on neuronal development and adult cognitive function in both humans and rodents. MS is associated with persistent dysregulations in neurotransmitter systems, including the serotonin (5-HT) pathway, which is pivotal for mood stabilization and stress-coping mechanisms. Although the novel cannabinoid receptor, GPR55, is recognized for its influence on learning and memory, its implications on the function and sy
Background: The norepinephrine system supports critical brain functions including arousal and memory. Norepinephrine neurons located in the locus coeruleus (LC) have been shown to gradually degenerate with normal aging and in neurodegenerative conditions. Pathology of the LC has been hypothesized to play a role in the onset of Alzheimer's disease (AD). Recent studies have found that a novel type of MR imaging, neuromelanin-sensitive MRI (NM-MRI) is capable of capturing decline in LC integrity wi
Abstract Background The use of cannabis for symptoms of endometriosis was investigated utilising retrospective archival data from Strainprint Technologies Ltd., a Canadian data technology company with a mobile phone application that tracks a range of data including dose, mode of administration, chemovar and their effect on various self-reported outcomes, including pelvic pain. Methods A retrospective, electronic record-based cohort study of Strainprint™ users with self-reported endometriosis was
Holistic management strategies for ERPP should be incorporated into routine counselling when discussing conservative, medical and or surgical treatments for endometriosis. The growing evidence presented for the use of holistic management strategies gives hope to those patients who cannot have, or don't respond to conventional approaches and as an adjunct alongside standard treatments. These findings should be incorporated into the routine counselling when seeing patients in the gynaecology outpa
Peer-reviewed industrial hemp research by Stacy Castellanos; Alexis Cooke; Sedona L. Koenders; Neena Joshi; Christine Miaskowski; Margot Kushel; Kelly R. Knight published in SSM - Mental Health (2023).
Results illustrate the importance of conducting assessments for both tobacco and cannabis use among cancer patients during and after cancer treatment, regardless of the cannabis regulatory environment. Given previous data indicating harms from co-use and continued tobacco use during cancer treatment, this issue introduces new priorities for cancer care delivery and research.
Providing patient-centered care to manage chronic pain and opioid use disorder (OUD) is associated with improved health outcomes. However, adopting a holistic approach to providing care is often challenging in rural communities. This study aims to identify and contrast challenges to providing patient-centered care from the perspective of patients and providers. A participatory design approach was adopted to elicit the perceptions of providers and patients with lived experiences of chronic pain a
Stress can have a significant impact on the daily lives of individuals and can increase vulnerability to a number of medical conditions. This study aims to estimate the ratio of male to female participants in acute social stress research in healthy individuals. We examined original research articles published over the last 20 years. Each article was screened to determine the total number of female and male participants. We extracted data from 124 articles involving a total of 9539 participants.
Endometriosis is a complex gynecological condition affecting 10% of women globally, characterized by the growth of endometrial-like tissue outside the uterus, leading to chronic pelvic pain, infertility, reduced quality of life, and a risk of cancer. This review examines the multifaceted aspects of endometriosis, including its causes, diagnostic approaches, and management strategies. Genetic and environmental factors, hormonal influences, and immunological dysregulation are addressed as potentia
The results revealed the anti-inflammatory effect of sertraline for RWPE-1 cells and EAP mice, and the potential mechanism was regulating the TRPV1 channel. It indicated that sertraline might serve as a complementary anti-inflammatory agent for CP.
Here we consider psychedelics with respect to their mechanisms of action, use, and implications for our understandings of brain and mind. This review is somewhat nontraditional in its scope, with discussions of both basic facts as well as theoretical speculations. We chose this approach given the unique historical context we find ourselves in at present. While we have decades of investigations to draw upon with respect to the clinical science and neuropsychopharmacology of psychedelics, we are a
The devastating effects of the COVID-19 pandemic have underscored the significant threat that infectious diseases pose to our society. Pregnancy represents a period of heightened vulnerability to infections, which can compromise maternal health and increase the risk of neurodevelopmental disorders in offspring. Preclinical and clinical investigations suggest a potential association between maternal immune activation (MIA), which is triggered by viral or bacterial infections, and increased risk f
Peer-reviewed industrial hemp research by Barbara Emons; Larissa Arning; Vera-Estelle Makulla; Maria-Theresia Suchy; Dimitrios Tsikas; Thomas Lücke; Jörg T. Epplen; Georg Juckel; Patrik Roser published in Annals of General Psychiatry (2023).
In 2021, 131 million adult Americans reported drinking alcohol in the last month, despite the well-known consequences of alcohol consumption. While alcohol use disorders (AUDs) are associated with both mood and chronic pain disorders, the relationship between alcohol drinking and affective and nociceptive behaviors remains unclear. Corticotropin releasing factor receptor-1 (CRF1) has been implicated in alcohol drinking, affective states, and pain sensitivity, often in a sex-dependent manner. In
CSL demonstrated antidepressant-like and anti-inflammatory effects in an LPS-induced neuroinflammation model, likely through the modulation of cytokine expression and mast cell activity. These results suggest the potential of CSL as a therapeutic option for treating inflammation-related depression.
In people with SCZ-CUD, a modest single dose of oral THC was associated with worse cognitive functioning without symptom exacerbation several hours after administration, and a THC dose-response effect was seen for negative symptoms.
Neuroinflammation worsens CHF-related cognitive impairment through neuroplasticity disorder, tied to intestinal flora dysbiosis. PDE4 emerges as a potential therapeutic target. These findings provide insightful perspectives on the heart-gut-brain axis.
Novel psychoactive substances (NPS), which emerged at the beginning of the 2000s have become a serious and internationally complex situation. These emerging drugs are mostly synthetic and analog derivatives of existing controlled drugs. They are sold ubiquitously not only on traditional markets but also through the Deep Web/Dark Web, where their regulation is even harder. The most important groups comprise synthetic cannabimimetics, cathinones and psychodysleptic phenethylamines. The variety and
The above combination of non-pharmacological interventions can reduce irritability in patients with dementia and caregivers' burden.
Peer-reviewed industrial hemp research by Marco Mariani; Antonio De Simone; R Aorn published in Journal of Anesthesia Analgesia and Critical Care (2023).
There is a need to concomitantly study the two systems' mechanistic contribution to psychosis in order to establish more refined biological relevance.
Diabetes and related acute and long-term complications have a profound impact on cognitive, emotional, and social behavior, suggesting that the central nervous system (CNS) is a crucial substrate for diabetic complications. When anxiety, depression, and cognitive deficits occur in diabetic patients, the symptoms and complications related to the disease worsen, contributing to lower quality of life while increasing health care costs and mortality. Experimental models of diabetes in rodents are a
Pain is a prevalent symptom among cancer patients and survivors. Psychoactive substance use (PSU) is associated with both the presence and severity of pain. However, little is known about this association in the context of cancer. The primary objective was to compare the prevalence of PSU and its relationship with pain during and after cancer. PSU was defined as the use of nonmedication substances (alcohol, tobacco, e-cigarettes, cannabidiol, and cannabis), with frequency categorized as at least