Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
Interest in cannabinoids' therapeutic potential in mental health is growing, supported by evidence of the involvement of the endocannabinoid system in psychiatric disorders such as anxiety, depression, and addiction. While the major cannabinoids cannabidiol (CBD) and Δ9-tetrahydrocannabinol (Δ9-THC) have been more extensively researched, approximately 120 minor cannabinoids from the cannabis plant have been identified. Although some displayed promising pharmacological profiles, research on their
Abstract Long coronavirus disease (COVID) is characterized by persistent symptoms following severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and has emerged as a significant health concern. As SARS‐CoV‐2 evolved from the wild‐type strain to the Alpha, Beta, Delta, and Omicron variants, there may be a variant‐specific influence on long COVID akin to the acute disease. This review aims to summarize our current knowledge of variant‐specific influences in long COVID incidence,
End-of-life family caregivers experience disrupted sleep with negative effects and inadequate support. Clinicians must assess sleep, offer sleep interventions, and provide more supports to hospice family caregivers.
Peer-reviewed industrial hemp research by Crawford Strunk; Andrew Campbell; Raffaella Colombatti; Biree Andemariam; Rachel Kesse‐Adu; Marsha Treadwell; Baba Inusa published in BMC Proceedings (2020).
An association between CBMP treatment and improvements in anxiety, sleep quality, and general HRQoL was observed in patients with ADHD. Treatment was well tolerated at 12 months. Results must be interpreted with caution as a causative effect cannot be proven. These results, however, do provide additional support for future evaluation within randomized controlled trials.
Peer-reviewed industrial hemp research by Rachel M. Kalbfell; Devin J. Rettke; Ken Mackie; Keisuke Ejima; Jaroslaw Harezlak; Isabella L. Alexander; Jim Wager‐Miller; Blair D. Johnson; Sharlene D. Newman; Keisuke Kawata published in iScience (2023).
Before assuming its role in the mature brain, serotonin modulates early brain development across phylogenetically diverse species. In mice and humans, early-life SSRI exposure alters the offspring's brain structure and is associated with anxiety and depression-related behaviors beginning in puberty. However, the impact of early-life SSRI exposure on brain circuit function is unknown. To address this question, we examined how developmental SSRI exposure changes fear-related brain activation and b
Peer-reviewed industrial hemp research by Llewellyn Mills; Adrian Dunlop; Mark Montebello; Jan Copeland; Raimondo Bruno; Meryem Jefferies; Iain S. McGregor; Nicholas Lintzeris published in Substance Abuse Treatment Prevention and Policy (2022).
Our results identify trends in language use during the first year of the pandemic and suggest that both the content of responses and overall sentiments are linked to mental health.
Peer-reviewed industrial hemp research by Cerina Lee; Jessica M. Round; Scott Klarenbach; John G. Hanlon; Elaine Hyshka; Jason R.B. Dyck; Dean T. Eurich published in Harm Reduction Journal (2021).
The serotonin (5-hydroxytryptamine) system represents a crucial neurotransmitter network that regulates mood, behavior, and cognitive functions, playing a significant role in the pathogenesis and progression of depression. Although this perspective faces significant challenges, the serotonin system continues to exert substantial modulatory effects on specific aspects of psychological functioning and actively contributes to multiple pathological processes in depression development. Therefore, thi
Peer-reviewed industrial hemp research by George Ntoulas; Charalampos Brakatselos; Gerasimos Nakas; Michail-Zois Asprogerakas; Foteini Delis; Leonidas J. Leontiadis; George Trompoukis; Costas Papatheodoropoulos; Dimitrios Gkikas; Dimitrios Valakos published in Translational Psychiatry (2024).
Disinformation-false information intended to cause harm or for profit-is pervasive. While disinformation exists in several domains, one area with great potential for personal harm from disinformation is healthcare. The amount of disinformation about health issues on social media has grown dramatically over the past several years, particularly in response to the COVID-19 pandemic. The study described in this paper sought to determine the characteristics of multimedia social network posts that lea
The components of the endogenous cannabinoid system are widely expressed in the gastrointestinal tract contributing to local homeostasis. In general, cannabinoids exert inhibitory actions in the gastrointestinal tract, inducing anti-inflammatory, antiemetic, antisecretory, and antiproliferative effects. Therefore, cannabinoids are interesting pharmacological compounds for the treatment of several acute intestinal disorders, such as dysmotility, emesis, and abdominal pain. Likewise, the role of c
Cognitive impairment is a very prominent problem in elderly patients with chronic schizophrenia. Elderly schizophrenia patients with cognitive impairment tended to have more depressive mood, more psychotic symptoms and worse activities of daily living. Hobbies will help prevent cognitive impairment in elderly patients with schizophrenia and may improve their cognitive function by influencing psychiatric symptoms. Therefore, we should encourage elderly patients with chronic schizophrenia to devel
Peer-reviewed industrial hemp research by Cecilia T. Costiniuk; Caroline A. MacCallum; Michael Boivin; Sergio Rueda; Gary Lacasse; Zach Walsh; Paul Daeninck; Shari Margolese; Enrico Mandarino; Jagpaul Kaur Deol published in Journal of Cannabis Research (2023).
Cognitive-behavioral therapy is a type of psychosocial intervention which aims to reduce the mental health conditions like depression, anxiety disorder, and others. Similarly, deep learning is a type of machine learning and artificial intelligence that imitates how humans gain certain types of knowledge. In this paper, deep learning has been used to effectively alleviate teenagers’ social anxiety and improve their social ability and the quality of social relations. It aims to conduct an in-depth
The purpose of this technical report is to provide an analysis of the available information on methyl 3,3-dimethyl-2-{[1-(pent-4-en-1-yl)-1H-indazole-3-carbonyl]amino}butanoate — also known as methyl 3,3-dimethyl-2-[1-(pent-4-en-1-yl)-1H-indazole-3-carboxamido]butanoate — (MDMB-4en-PINACA), a synthetic receptor cannabinoid agonist (synthetic cannabinoid) that has recently emerged on the drug market in Europe, in order to support the risk assessment of the substance which has been requested by th
Psychosis and agitation are among the most distressing neuropsychiatric symptoms (NPSs) of Alzheimer's disease (AD), linked to faster disease progression and earlier admission to nursing homes. While nonpharmacological treatments may alleviate mild behavioral symptoms, more severe syndromes often require pharmacological intervention. Brexpiprazole is the only medication approved for agitation in AD, although its limited clinical efficacy has raised criticism. No drugs have been approved for trea
The endocannabinoid system (ECS), which is composed of endocannabinoids (eCBs), cannabinoid receptors (CBRs), and associated signaling molecules, has been identified within the brain. In neuropathic pain animal models and patients, long-lasting alterations in the ECS have been observed. These changes of neurons and glial cells in the ECS contribute to the modulation of neuropathic pain. Intervention strategies such as the activation of CBRs, the enhancement of hydrolytic enzyme function, and the
Patients with insomnia experienced an improvement in sleep quality following the initiation of CBMPs in this medium-term analysis. Fewer than 15% of participants reported one or more adverse events. However, due to the limitations of the study design, further investigation is required before definitive conclusions can be drawn on the efficacy of CBMPs in treating insomnia.
Peer-reviewed industrial hemp research by Jussi Jylkkä; Aleksi Hupli; Aleksandra Nikolaeva; Sandra Alanen; Anna Erika Back; Sara Lindqvist; Andreas Krabbe; Maya Lavie‐Ajayi; Oskari Kantonen published in Journal of Cannabis Research (2023).
Journal of Psychiatry Research publishes high impact articles and case report and case studies in Psychiatry Research. The open access journal provides a platform to access the latest research in the field of psychiatry.
The results suggest that targeting cannabinoid receptors, particularly CB1 antagonists and CB2 agonists, can improve kidney function and reduce inflammatory responses, exerting a renal protective effect and maintaining therapeutic potential in various types of kidney disease.
Peer-reviewed industrial hemp research by Jeffrey I. Butler; Sherry Dahlke; Rashmi Devkota; Shovana Shrestha; Kathleen F. Hunter; Madeline Toubiana; Maya R. Kalogirou; Joanna Law; Melissa Scheuerman published in Drugs & Aging (2023).