Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
Medical benefits of cannabis and related compounds is widely known. Discovery of psychotropic plant cannabinoid Δ9-tetrahydrocannabinol have urged researchers to study more about the cannabinoid system and related therapeutics in the field of neurology and medicine. Where activation of cannabinoid receptor type 1 (CB1R) yielded in unwanted and serious side effects, discovery of cannabinoid receptor type 2 (CB2R) and its ligands gave a new hope. Till now there is limited success in this field bec
Epilepsy is a chronic non-communicable neurologic condition that affects all ages of people by enduring predisposition to generate seizures, unprovoked by any immediate central nervous system insult and by neurobiologic, cognitive, psychological and social consequences of seizure recurrences. In most of the cases, the cause of epilepsy remains unknown and undetermined. However a few factors such as head injury, infections, tumor in brain, stroke, substance abuse and hereditary factors are the pr
It was conducted as a descriptive study to examine the attitudes of students studying in the special education teaching department towards childhood epilepsy. This research is descriptive and descriptive in nature. The data required for the research was collected between 01 June 2024 and 31 July 2024. The study group consisted of 328 students studying in special education teaching. Sociodemographic and Epilepsy Questionnaire data collection form and Social Attitudes Towards Childhood Epilepsy Sc
Vagus nerve stimulation (VNS) has been used as an adjunctive therapeutic option for drug-resistant epilepsy for decades. Traditionally, the left vagus nerve is used for stimulation, while the right vagus nerve is rarely used. The long-term efficacy and safety of the right VNS (R-VNS) in humans are unknown. We presented three patients who were treated with R-VNS over a follow-up period of up to eight years. All three patients tolerated R-VNS well with minimal complications. R-VNS displayed reason
MDD is a complex mental illness shaped by the interplay between genetic vulnerability and environmental triggers. Its underlying pathophysiological processes are now understood to be influenced by epigenetic mechanisms. Growing evidence points to critical roles for DNA methylation, histone modification, and ncRNAs in driving transcriptional dysregulation within key brain regions implicated in MDD. These epigenetic alterations may underlie the persistent impairments in neuroplasticity following e
Abstract The present study has been explored the neuroprotective efficacy of myricitrin and unveil the mechanism of action via the regulation of Nrf2/ HO-1/ARE-dependent signaling cascade in hypoxic-ischemic (HI) induced brain injury of neonatal rats. Upon HI operation neonatal rats received 20 and 40mg/kg bw of myricitrin as intraperitoneally up to one week twice in a day. Myricitrin administration augmented HI induced increase of infarct volume and oedema of the brain, as well as improve neuro
Changes in the composition of gut microbiota have been associated with the development of Alzheimer’s disease (AD), and diverse primary mechanisms are proposed. However, research on this topic is still in the early stages, and many features of the microbiota-AD relationship are just starting to be revealed and understood. Obtaining a detailed knowledge of the complex connections and signaling pathways associated with the microbiota-gut-brain axis is critical for improving therapeutic strategies
Epilepsy is a neurological disorder affecting approximately 50 million people globally and is characterised by recurrent, unprovoked seizures resulting from abnormal, excessive synchronised firing of neurons. Developing new therapeutic targets and biomarkers is key to improving the diagnosis, treatment, and management. This scoping review examines the current literature on the preclinical and clinical applications of dietary interventions that target the neurolipidome in epilepsy. Specifically,
This review, conducted by the Andalusian Epilepsy Society, provides an update on recent advances in the treatment of drug-resistant epilepsy, focusing on three new anti-seizure drugs: cenobamate, fenfluramine and cannabidiol. These emerging drugs offer new therapeutic alternatives for patients with drug-resistant focal epilepsy, Dravet syndrome, and Lennox-Gastaut syndrome. The primary objective of this review is to provide healthcare professionals with an up-to-date overview of the efficacy, sa
Xia-Gibbs syndrome (XGS) is a rare intellectual disability (ID) syndrome caused by de novo AHDC1 pathogenic variants. We characterized clinical and molecular features of 16 Brazilian patients with XGS. Patient data were collected through semistructured interviews with family members, reanalysis of previous health and genetic assessments, and clinical reports from physicians. Genomic variants and their segregation were validated via Sanger sequencing. Statistical analyses were conducted to evalua
Results underscores the potential of cognitive stimulation for heightened cognitive abilities, promoting enhanced brain connectivity and information flow in Rett syndrome. These findings offer valuable markers for evaluating cognitive interventions and suggest gaming-related activities as effective tools for improving learning outcomes.
This study explores the intriguing phenomenon of action potentials reverberating and propagating in high-resistance tissues, such as gliosis, leading to the emergence of short circuits within the brain. Gliosis, characterized by increased tissue resistance, presents a unique environment for electrical signals. My research investigates the possible mechanisms behind these reverberations and their role in the creation of self-empowering short circuits that can potentially affect the entire brain's
This case report documents the treatment of a female patient with intractable temporal lobe epilepsy with secondary generalization. At the age of 13, the patient was hospitalized with ~120 seizures in a day, some of which were life-threatening. After hospital discharge, despite a regimen of multiple antiseizure medications, the patient still experienced ~90 seizures per day. After the interventions described in this work, over 500 neurofeedback sessions guided by EEG or qEEG data and adjunctive
This white paper introduces a first-of-its-kind quantum-integrated systems biology framework for understanding and reversing epilepsy. Combining quantum bioelectric modeling, AI pattern recognition, endocannabinoid system (ECS) recalibration, and miRNA-epigenetic mapping, the paper presents a multi-layered codex for decoding seizure initiation, propagation, and resolution. Core innovations include analysis of mitochondrial electron tunneling, ion channel decoherence, post-ictal entropy sinks, an
ABSTRACT Radix Astragalus (RA) has been used in the treatment of depression. Astragalus polysaccharide (APS) is one of the effective components of RA. However, the antidepressant mechanism of APS is still unclear. This research utilized 16S rRNA analysis, microbial analysis, and metabolomics analysis to elucidate the antidepressant mechanism of APS at both micro and macro levels. Correlation analysis was performed on the perspective of “behavioral indicators‐intestinal bacteria‐immune factors‐di
Background: Bibliometric analysis can be used to measure and evaluate scientific activities in certain areas, so we know where to focus our efforts. Epilepsies are mostly idiopathic and genetic, as in Dravet’s syndrome, linked to sodium channels. With this in mind, this paper delves into the published articles related to the involvement of sodium (Na+) channels in epilepsy, to get a better perspective of this specific area. Methods: The analysis was carried out by means of the scientific follow-
These results support the long-term safety and effectiveness of fenfluramine in patients with LGS, with no new safety signals identified, and sustained reductions in seizures and improvement in global functioning observed.
Cannabis (in all the varied methods of delivery) continues to garner significant attention as a potential therapeutic intervention for neurodegenerative disorders, including Parkinson's disease (PD). The recent legalization of personal use of cannabis products in some parts of the world has increased this interest and with it, potential availability to many more people. However, such access has led to more questions than answers for both patients and health care professionals. These include what
Objective: To systematically evaluate the relationship between IL-1 and refractory epilepsy and its diagnostic value. Methods: The database was searched in PubMed, The Cochrane Library, Web of Science and other databases. The language was English. The time limit was from the establishment of the database to the relevant literature on January 10, 2023. Stata 15.1 software was used for specificity, sensitivity, publication bias, meta-regression analysis and heterogeneity test for specificity to an
Peer-reviewed industrial hemp research by Renad M Alsolamy; Talah Almaddah; Ammar Aljabri; Hadeel A Maaddawi; Faris Alzahrani; Maha Gashlan published in Cureus (2023).
Peer-reviewed industrial hemp research by Elizabeth Berry‐Kravis; Randi J. Hagerman; Jonathan Cohen; Dejan B. Budimirovic; Caroline B. Buchanan; Natalie Silove; Nancy Tich; Anthony Thibodeau; Thomas W Dobbins; Terri Sebree published in Journal of Neurodevelopmental Disorders (2025).
Case Presentation: AGRB, male, 9 years old, 52kg, previously healthy, born and raised in Pirambu, Bebedouro village, Sergipe.Adtted on 10/09/2022 to the pediatrics sector of the Sergipe Emergency hospital, reporting headache, fever and vomiting for 7 days, with subsequent evolution with pain in the posterior region of the right thigh, in addition to low back pain.Physical examination showed normal breathing and heart rate.Decreased strength in lower limbs, being worse on the left side.No patella
Peer-reviewed industrial hemp research by Janete Sofia Abreu Henriques published in Open Repository of the University of Porto (University of Porto) (2019).
Being refractory is a significant challenge for one third of patients with epilepsy, and there is a need for new treatments. Non-periodic Stimulation (NPS) has shown promise in animal models, but it involves invasive technology. Consequently, non-invasive non-periodic Acoustic Non-periodic Stimulation (ANPS) has been developed based on NPS, with the hope that it could offer anticonvulsant effects. However, it is essential to ensure the safety of ANPS, particularly in individuals with refractory