Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
Managing epilepsy in people with an intellectual disability remains a therapeutic challenge and must take into account additional issues such as diagnostic difficulties and frequent drug resistance. Advances in genomic technologies improved our understanding of epilepsy and raised the possibility to develop patients-tailored treatments acting on the key molecular mechanisms involved in the development of the disease. In addition to conventional antiseizure medications (ASMs), ketogenic diet, hor
Chinese herbal medicine has a long history of use for treating epilepsy. Because of the side effects of Western antiepileptic therapy and the quest for more accessible treatment, complementary and alternative medicines have become popular. Traditional Chinese medical diet therapy appears to be safe and effective. We searched PubMed and the Cochrane Library through November 2020 for the use of traditional Chinese medicine in clinical settings, including plants, fungi, and animals. Combinations of
Febrile Infection-Related Epilepsy Syndrome (FIRES) is a unique catastrophic epilepsy syndrome, and the development of drug-resistant epilepsy (DRE) is inevitable. Recently, anakinra, an interleukin-1 receptor antagonist (IL-1RA), has been increasingly used to treat DRE due to its potent anticonvulsant activity. We here summarized its effects in 38 patients (32 patients with FIRES and six with DRE). Of the 22 patients with FIRES, 16 (73%) had at least short-term seizure control 1 week after star
Peer-reviewed industrial hemp research by Tamar Sapir; Aditya Kshirsagar; Anna Gorelik; Tsviya Olender; Ziv Porat; Ingrid E. Scheffer; David B. Goldstein; Orrin Devinsky; Orly Reiner published in Nature Communications (2022).
Rett syndrome (RTT) and CDKL5 deficiency disorder (CDD) are two rare X-linked developmental brain disorders with overlapping but distinct phenotypic features. This review examines the impact of loss of methyl-CpG-binding protein 2 (MeCP2) and cyclin-dependent kinase-like 5 (CDKL5) on clinical phenotype, deficits in synaptic- and circuit-homeostatic mechanisms, seizures, and sleep. In particular, we compare the overlapping and contrasting features between RTT and CDD in clinic and in preclinical
The pore-forming subunits (α subunits) of voltage-gated sodium channels (VGSC) are encoded in humans by a family of nine highly conserved genes. Among them, <i>SCN1A</i>, <i>SCN2A</i>, <i>SCN3A</i>, and <i>SCN8A</i> are primarily expressed in the central nervous system. The encoded proteins Nav1.1, Nav1.2, Nav1.3, and Nav1.6, respectively, are important players in the initiation and propagation of action potentials and in turn of the neural network activity. In the context of neurological diseas
De novo pathogenic variants in <i>STXBP1</i> encoding syntaxin1-binding protein (STXBP1, also known as Munc18-1) lead to a range of early-onset neurocognitive conditions, most commonly early infantile epileptic encephalopathy type 4 (EIEE4, also called STXBP1 encephalopathy), a severe form of epilepsy associated with developmental delay/intellectual disability. Other neurologic features include autism spectrum disorder and movement disorders. The progression of neurologic symptoms has been repor
Early-onset Alzheimer's disease (AD) is associated with variants in amyloid precursor protein (APP) and presenilin (PSEN) 1 and 2. It is increasingly recognized that patients with AD experience undiagnosed focal seizures. These AD patients with reported seizures may have worsened disease trajectory. Seizures in epilepsy can also lead to cognitive deficits, neuroinflammation, and neurodegeneration. Epilepsy is roughly three times more common in individuals aged 65 and older. Due to the numerous a
Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents a key domain of healthcare, which currently has limited, adverse-effect prone treatment options, and probiotics may hold the potential to be a novel, customizable treatment for depression. Clinical depression is a common, potentially debilitating condition that may be amenable to a p
The highly invasive nature of glioblastoma imposes poor prospects for patient survival. Molecular evidence indicates glioblastoma cells undergo an intriguing expansion of phenotypic properties to include neuron-like signaling using excitable membrane ion channels and synaptic proteins, augmenting survival and motility. Neurotransmitter receptors, membrane signaling, excitatory receptors, and Ca<sup>2+</sup> responses are important candidates for the design of customized treatments for cancers wi
An expansive list of potential causative agents were identified from a large set of literature-reported SJS/TEN cases, which warrant future investigation to understand risk factors and clinical manifestations of SJS/TEN in different populations.
Peer-reviewed industrial hemp research by Renandro de Carvalho Reis; Kelson James Almeida; Luciano da Silva Lopes; Cíntia Maria de Melo Mendes; Edson Bor‐Seng‐Shu published in Epilepsy & Behavior (2019).
Peer-reviewed industrial hemp research by Sara Mole; Angela Schulz; Ëben Badoe; Samuel F. Berkovic; Emily de los Reyes; Simon Dulz; Paul Gissen; Norberto Guelbert; Charles Marques Lourenço; Heather Mason published in Orphanet Journal of Rare Diseases (2021).
Peer-reviewed industrial hemp research by Ali A. Asadi‐Pooya; Armin Attar; Mohsen Moghadami; Iman Karimzadeh published in Neurological Sciences (2020).
Peer-reviewed industrial hemp research by Jingzhan Zhang; Zixian Lei; Xu Chen; Juan Zhao; Xiaojing Kang published in Clinical Reviews in Allergy & Immunology (2021).
Peer-reviewed industrial hemp research by Adam Strzelczyk; Sameer M. Zuberi; Pasquale Striano; Felix Rosenow; Susanne Schubert‐Bast published in Orphanet Journal of Rare Diseases (2023).
Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases generating a larger pool of peptides within cells. Thousands of intracellular peptides have been sequenced in plants, yeast, zebrafish, rodents, and in human cells and tissues. Relative levels of intracellular peptides undergo changes in human diseases and also when cells are stimulated, corroborating their biological fu
COVID-19 still represents a major issue for patients with lymphoid malignancies, especially those on therapy, because of immune suppression and suboptimal responses to vaccination. Davis et al report on their experience with double dose tixagevimab-cilgavimab preexposure prophylaxis in a cohort of 251 patients with chronic lymphocytic leukemia, B-cell lymphomas, multiple myeloma, or B-cell acute lymphoblastic leukemia, 63% of whom had received 3 doses of the SARS-CoV-2 vaccine. Breakthrough infe
We performed a systematic literature review and narrative synthesis according to a pre-registered protocol (Prospero: CRD42022376561) to identify the evidence associated with the burden of illness in Dravet syndrome (DS), a developmental and epileptic encephalopathy characterized by drug-resistant epilepsy with neurocognitive and neurobehavioral impairment. We searched MEDLINE, Embase, and APA PsychInfo, Cochrane's database of systematic reviews, and Epistemonikos from inception to June 2022. No
Generally, the prevalence of epilepsy does not exceed 0.9% of the population and approximately 70% of epilepsy patients may be adequately controlled with antiepileptic drugs (AEDs). Moreover, status epilepticus (SE) or even a single seizure may produce neurodegeneration within the brain and SE has been recognized as one of acute brain insults leading to acquired epilepsy via the process of epileptogenesis. Two questions thus arise: (1) Are AEDs able to inhibit SE-induced neurodegeneration? and (
Voltage-gated sodium channel Na<sub>v</sub>1.6 plays a crucial role in neuronal firing in the central nervous system (CNS). Aberrant function of Na<sub>v</sub>1.6 may lead to epilepsy and other neurological disorders. Specific inhibitors of Na<sub>v</sub>1.6 thus have therapeutic potentials. Here we present the cryo-EM structure of human Na<sub>v</sub>1.6 in the presence of auxiliary subunits β1 and fibroblast growth factor homologous factor 2B (FHF2B) at an overall resolution of 3.1 Å. The over
These data expand the genetic and phenotypic spectrum of <i>STX1B</i>-related epilepsies to a diverse range of epilepsies that span the International League Against Epilepsy classification. Variants in <i>STX1B</i> are protean and contribute to many different epilepsy phenotypes, similar to <i>SCN1A</i>, the most important gene associated with fever-associated epilepsies.
Peer-reviewed industrial hemp research by Xiuqin Rao; Fuzhou Hua; Lieliang Zhang; Yue Lin; Fang Pu; Shoulin Chen; Jun Ying; Xifeng Wang published in Journal of Translational Medicine (2022).