Hemp Research — Page 33

Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.

Sex Differences in the Effects of Controlled Circadian Dysregulation on Gut Microbiome and Intestinal Barrier Architecture (2026)

ABSTRACT Disturbances of 24-hour or circadian rhythms imposed by everyday irregular work and/or social schedules have been linked to vascular disease, including ischemic stroke. Using an established shift work-like paradigm and preclinical model for ischemic stroke, we have shown that environment-induced circadian dysregulation exacerbates stroke outcomes differentially to a greater extent in male than female rats. Because more severe stroke outcomes and circadian rhythm disturba

Project Twenty21 Australia: A Case Study of the Treatment of Chronic Pelvic Pain Due To Endometriosis with Cannabidiol Oil (2025)

Project Twenty21 Australia was an open label, prospective observational cohort study investigating the effectiveness of medicinal cannabis in alleviating chronic pain, anxiety, PTSD and multiple sclerosis. Participants completed validated questionnaires at baseline then three-monthly (up to 12 months) to assess pain, sleep, mood, quality of life and perceived impression of change. This case study describes a 23-year-old woman who was a participant in Project Twenty21 Australia who presented with

Role of the Intestinal Microbiome, Intestinal Barrier and Psychobiotics in Depression (2021)

The intestinal microbiota plays an important role in the pathophysiology of depression. As determined, the microbiota influences the shaping and modulation of the functioning of the gut–brain axis. The intestinal microbiota has a significant impact on processes related to neurotransmitter synthesis, the myelination of neurons in the prefrontal cortex, and is also involved in the development of the amygdala and hippocampus. Intestinal bacteria are also a source of vitamins, the deficiency of whic

Fmr1 mutation reshapes gut microbiome structure, diversity, intestinal barrier integrity, and function in a sex and genotype-dependent manner (2026)

Fragile X Syndrome (FXS) is the leading monogenic cause of autism spectrum disorder (ASD), caused by mutation in the Fmr1 gene. In addition to cognitive and behavioral challenges, FXS patients often experience altered gut microbiome-induced gastrointestinal (GI) problems. Evidence suggests that an altered gut microbiome can disrupt mucosal barrier and promote inflammation, leading to impaired intestinal barrier integrity and function. However, the mechanisms by which the gut microbiome alters th

Gut microbiome-derived prolyl peptidases from Segatella copri and Stenotrophomonas maltophilia degrade immunogenic gliadin peptides and restore intestinal barrier integrity in a Celiac disease model (2025)

Abstract Celiac disease (CeD) is an autoimmune enteropathy triggered by gluten-derived peptides that resist gastrointestinal digestion, notably the proline-rich 33-mer and 11-mer gliadin epitopes. Here, we describe a rational, data-centric strategy to identify gut microbiome-derived prolyl peptidases capable of degrading these immunogenic peptides. Integrating metagenomic mining with structure-based in silico screening, we identified two novel enzymes PSP692 an

Treatment of Nonalcoholic Fatty Liver Disease through Changes in Gut Microbiome and Intestinal Epithelial Barrier (2021)

Nonalcoholic fatty liver disease (NAFLD) is a leading liver disease worldwide with a prevalence of approximately 25% among adult population. The highest prevalence is observed in Middle East and the lowest prevalence in Africa. NAFLD is a spectrum of liver disorders ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). Pro-inflammatory diet, overweight/obesity, inflammation, insulin resistance, prediabetes, type 2 diabetes, dyslipidemia, disrupted gut microbiome, and impaired int

The effect of camelina oil (α-linolenic acid) and canola oil (oleic acid) on lipid profile, blood pressure, and anthropometric parameters in postmenopausal women (2020)

IntroductionCold-pressed camelina oil (Camelina sativa) is rich in polyunsaturated fatty acids and may have a beneficial effect on the reduction of cardiovascular risk.Material and methodsIn this study, we investigated the parameters contributing to the development of cardiovascular diseases, such as dietary intake, nutritional status, blood pressure, and lipid profile. Sixty postmenopausal women with dyslipidaemia were randomly assigned to two oil groups: camelina oil and canola oil. The subjec

The Effects of a Low Linoleic Acid/α-Linolenic Acid Ratio on Lipid Metabolism and Endogenous Fatty Acid Distribution in Obese Mice (2023)

A reduced risk of obesity and metabolic syndrome has been observed in individuals with a low intake ratio of linoleic acid/α-linolenic acid (LA/ALA). However, the influence of a low ratio of LA/ALA intake on lipid metabolism and endogenous fatty acid distribution in obese patients remains elusive. In this investigation, 8-week-old C57BL/6J mice were randomly assigned to four groups: low-fat diet (LFD) as a control, high-fat diet (HFD), high-fat diet with a low LA/ALA ratio (HFD+H3L6), and high-f

Gamma Linolenic Acid: Sources and Functions (2020)

AbstractGamma‐linolenic acid (GLA,cis6,cis9,cis12‐octadecatrienoic acid) is a conditionally essential fatty acid of the n‐6 family. It is produced in the mammalian body from enzymatic desaturation of linoleic acid, an essential fatty acid that must be supplied by the diet. It is widely distributed in plant kingdom in trace amounts, and is not present in major commercial vegetable seed oils. It is present in seeds of many species belonging to families Aceraceae, Boraginaceae, Cannabinaceae, Lilia

Flexural Performance of Reinforced Concrete (RC) Beam Strengthened by UHPC Layer (2022)

Abstract Reinforced concrete (RC) structures may be subjected to an increase in load, severe environmental attack, and other factors that may lead to deterioration. Strengthening/repair techniques are typically used to upgrade the strength or enhance the durability which extends the service life of the structures. In the current study, the behavior of reinforced concrete beam strengthening by the UHPC layer with/without construction joints was investigated. The effect of the steel/GFRP b

Flexural (Moment) Capacity of Ultra-high Performance Fiber Reinforced Concrete Beams (2021)

<p>Ultra-High Performance Fiber Reinforced Concrete (UHPFRC) is a relatively new generation of cementitious material exhibiting exceptional mechanical characteristics. One of the main applications of this new material is strengthening existing bridges and the construction of new Igirders during the rehabilitation process. Previous research on (UHPFRC) beam girders and prestressed girders found the analytical moment capacity to be 76% of the experimental (test) results. A method based on st

Flexural (Moment) Capacity of Ultra-high Performance Fiber Reinforced Concrete Beams (2021)

<p>Ultra-High Performance Fiber Reinforced Concrete (UHPFRC) is a relatively new generation of cementitious material exhibiting exceptional mechanical characteristics. One of the main applications of this new material is strengthening existing bridges and the construction of new Igirders during the rehabilitation process. Previous research on (UHPFRC) beam girders and prestressed girders found the analytical moment capacity to be 76% of the experimental (test) results. A method based on st

Flexural behavior of polyvinyl alcohol ( PVA) fiber concrete beam reinforced with hybrid glass fiber reinforced polymer ( GFRP) bars and steel bars (2025)

Abstract Degradation of steel reinforced concrete (RC) infrastructure due to reinforcement corrosion results in significant damage and economic loss. In this paper, glass fiber reinforced polymer (GFRP) bars are used to replace the steel bars at the corners, and the steel bars that are easy to be corroded are placed inside the member. The flexural performance of polyvinyl alcohol (PVA) fiber concrete beams reinforced with hybrid GFRP and steel bars is studi