Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
Background: Chronic pain poses a major global health burden, often inadequately managed by conventional analgesics due to limited efficacy and side effects. In this context, plant-based therapies offer a promising alternative. This study aimed to evaluate the antioxidant and analgesic potential of four medicinal plants traditionally used for pain relief: Morus alba, Angelica archangelica, Valeriana officinalis, and Passiflora incarnata. Methods: Phytochemical analyses quantified total phenolic a
This study proposes that re-living trauma near death is a recognisable phenomenon with physical and psychological impacts that can be ameliorated with improved clinical knowledge and appropriate management as a new GT. Further research is needed to enable past trauma identification at the end of life, and trauma-informed safe interventions at the end of life are an urgent need.
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory disease of the urinary bladder, characterized by chronic pain, increased urinary frequency, urgency, and nocturia. Currently, no therapeutic option consistently provides long-term relief for all IC/BPS patients, likely due to the largely unknown mechanisms underlying the disease's development and progression. IC/BPS is considered a multifactorial disorder with a complex pathobiology that ultimately leads to unresolved
Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system. Cannabinoid CB1 and CB2 receptors are G protein-coupled receptors present from the early stages of gestation, which is involved in various physiological processes, including appetite, pain-sensation, mood, and memory. Due to the lipophilic nature of cannabinoids, it was initially thought that these compounds exert several biological effects by disrupting the cell membrane nonspecifically. Recent biochemic
• Medical cannabis authorization had little to no effect on benzodiazepine usage among patients prescribed regular benzodiazepine treatment in Alberta, Canada. • Further clinical research is needed to investigate the potential impact of medical cannabis as an alternative to benzodiazepine medication.
We found substantial demand for MC use among breast cancer patients. Health literacy, social support, monthly household income, and attitudes about MC were significantly associated with demand for MC use. Therefore, improving health literacy, social support, and attitudes about MC, especially among breast cancer patients, could help increase demand for MC as a complementary and alternative medicine alongside cancer treatment.
It has been reported that cannabis consumption affects the anterior cingulate cortex (ACC), a structure with a central role in mediating the empathic response. In this study, we compared psychometric scores of empathy subscales, between a group of regular cannabis users (85, users) and a group of non-consumers (51, controls). We found that users have a greater Emotional Comprehension, a cognitive empathy trait involving the understanding of the "other" emotional state. Resting state functional M
Nicotine and cigarette/tobacco use continue to be a prevalent public health issue worldwide. The transition to nicotine addiction occurs through an allostatic cycle involving the stages of binging/intoxication, withdrawal/negative affective states, and preoccupation/anticipation. This review focuses on the psychological, neurobiological, and molecular mechanisms contributing to the negative affective state during withdrawal from nicotine with an emphasis on stress and how social defeat stress ca
Findings suggest that 40% of Vermont young adults in the study were unaware of current state cannabis policy and that policy knowledge was lower in younger, less educated, Hispanic, and non-White young adults. Future research should explore using a measure of policy knowledge as an exposure or moderator variable to better quantify the effects of changes in cannabis legal status on perceptions and use in young people.
The number of papers published and the research enthusiasm in this field show a steady upward trend. However, there is a lack of influential institutions and scholars, and there is relatively little research collaboration across countries/regions/institutions. The scientific research influence of institutions and scholars in most European and American countries/regions is significantly ahead of that of institutions and scholars in Asian and African countries/regions. But Sun Yat Sen University i
This is the first study showing anxiolytic effect of an α7-nAChR agonist in humans. VQW-765 is a promising candidate to be developed for on-demand treatment of social anxiety disorder.
Hepatic encephalopathy (HE) reflects a wide spectrum of frequent and complex neurological complications that are associated with advanced liver diseases. It significantly impacts the quality of life and daily activities of those affected. Despite many investigations, the precise pathophysiology of HE is still under discussion. One contributing factor believed to be responsible for HE is the accumulation of neurotoxic substances in the brain such as ammonia, mercaptans, short-chain fatty acids, a
CBD interferes with contextual fear memory and the dosage regimen of treatment seems to be important. Moreover, we cannot rule out the involvement of emotional aspects in these processes related to fear memory.
This visual analysis summarizes research trends and developments of sciatic nerve injury treatment and predicts potential research frontiers and hot directions.
ABSTRACT Alzheimer’s disease (AD) and other neurodegenerative dementias have a progressive course, impairing cognition, functional capacity, and behavior. Most studies have focused on AD. Severe dementia is associated with increased age, higher morbidity-mortality, and rising costs of care. It is fundamental to recognize that severe dementia is the longest period of progression, with patients living for many years in this stage. It is the most heterogeneous phase in the process, with different a
Peer-reviewed industrial hemp research by Sonam Nain; Nakambam Manoranjan Singh; Anne Katrin Schlag; Michael Barnes published in Journal of Cannabis Research (2025).
This study underscores the urgency of developing targeted, youth-centred interventions that resonate with the lived realities of adolescents, aiming not only to reduce substance use but also to address the broader psychosocial factors contributing to simultaneous polysubstance use. By shedding light on the complex dynamics of adolescent polysubstance use, our research contributes to the ongoing dialogue on effective prevention strategies, advocating for a holistic approach encompassing education
This is the third and final update for the 2020 report Noninvasive Nonpharmacological Treatment for Chronic Pain 1 (available at https://effectivehealthcare.ahrq.gov/products/noninvasive-nonpharm-pain-update/research),covering the period January 2021 through March 2022.The 2020 report addressed benefits and harms of noninvasive nonpharmacological therapy for five common chronic pain conditions: low back pain (LBP); neck pain; knee, hip, or hand osteoarthritis (OA); fibromyalgia (FM); and tension
The widespread use of marijuana in the context of increasing legalization has both short- and long-term health implications. Although various modes of marijuana use-smoked, vaped, or ingested-may lead to a wide scope of potential systemic effects, we focus here on inhalational use of marijuana as the most common mode with the lung as the organ that is most directly exposed to its effects. Smoked marijuana has been associated with symptoms of chronic bronchitis and histopathologic changes in airw
Schizophrenia is a psychiatric condition characterized by a profound mental illness that impairs an individual's capacity to function in both social and cognitive domains.Individuals diagnosed with schizophrenia display psychopathological symptoms that are categorized as positive, negative, and cognitive.According to some estimates, nearly 98% of people with schizophrenia have cognitive deficits and perform below their expected cognitive capacity, which depends on their premorbid intelligence an
The federal government of the USA is in the process of reclassifying cannabis from a schedule I controlled substance to a schedule III controlled substance [1]. Most individual states had implemented medical cannabis programs prior to this reclassification, with Florida implementing a medical cannabis program in 2016 via expanding their earlier compassionate use program [2]. As of the summer of 2024, there are over 880,000 Florida registrants, making Florida one of the largest state medical cann
Brittany Weger, PharmD Candidate; Ali Goforth, PharmD Candidate; Alexandra Cunha, PharmD Candidate; Shaina Schwartz, PharmD, BCPP; Julie Cooper, PharmD, BCPS, BCCPHigh Point University, High Point, NCType: Original Research. Background: Individuals with depression are at an increased risk of cardiovascular disease, risk of an with of of risk of an with of risk risk risk of risk risk PharmD, of Original Research. are of are with are of with at of with of of at of of of an at of of at of of of at
Early adversity, the loss of the inhibitory GABAergic interneuron parvalbumin, and elevated neuroinflammation are associated with depression. Individuals with a maltreatment history initiate medicinal cannabis use earlier in life than non-maltreated individuals, suggesting self-medication. Female rats underwent maternal separation (MS) between 2 and 20 days of age to model early adversity or served as colony controls. The prelimbic cortex and behavior were examined to determine whether MS alters