Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
Post-COVID condition (PCC) is a complex syndrome characterized by the persistence of diverse symptoms-including respiratory, neurological, and psychiatric manifestations-that last for weeks or months after acute Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Epidemiological data indicate a higher prevalence among women and older adults, with significant impacts on daily functioning. The pathophysiology of PCC is multifactorial, involving immune dysregulation, viral persi
Resistant migraine characterizes those patients who have failed at least three classes of migraine prophylaxis. These difficult-to-treat patients are likely to be characterized by a high prevalence of psychological disturbances. A dysfunction of the endocannabinoid system (ECS), including alteration in the levels of endocannabinoid congeners, may underlie several psychiatric disorders and the pathogenesis of migraines. Here we explored whether the peripheral gene expression of major components o
<title>Abstract</title> Background Cannabis was legalised for medical purposes in 2016. Uptake was initially slow, but since 2019 there has been a large increase in the number of Australians who have been prescribed cannabis for medical reasons. Yet a significant number of consumers continue to treat their medical conditions via illicitly-sourced cannabis. Little is known about how these two groups of medical cannabis consumers differ. Methods The anonymous Cannabis-As-Medicine Survey 2022 (CAMS
The results indicated that undertaking cannabinoid therapy with PCP awareness or guidance from a cannabis clinician is associated with better outcomes.
Fatty acid binding proteins (FABPs) transport lipids in the brain and may be involved in the course of various neuropsychiatric syndromes, e.g., major depressive disorder (MDD), anxiety, schizophrenia, neurodegenerative disorders, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and substance use disorders (SUDs). However, the nature of this link is not sufficiently elucidated. To that end, we performed a comprehensive literature search on the role of FABPs in neu
tional biases.This understanding forms the foundation for developing targeted therapeutic strategies aimed at restoring balance within these neural systems and improving outcomes for individuals with these mental health conditions.Schizophrenia (SZ) is a complex neuropsychiatric disorder characterized by disruptions in cognitive, emotional,
Cannabis use during pregnancy is increasing; the study of adverse outcomes in cannabis-exposed pregnancies is therefore important. Previous articles in this series described increased risks of maternal adverse outcomes, fetal adverse outcomes, birth defects in newborns, and autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in childhood. This article examines neuropsychiatric adverse outcomes in offspring gestationally exposed to cannabis. Currently available rese
Peer-reviewed industrial hemp research by Gian DePamphilis; Eric Tirrell; Eugenia F. Kronenberg; Joshua C. Brown; Andrew M. Fukuda; Linda L. Carpenter published in Brain stimulation (2024).
Peer-reviewed industrial hemp research by Santosh Kumar; Gurudutt Pendyala; Sowmya V. Yelamanchili; Pankaj Seth; Sanjay B. Maggirwar; Jean M. Bidlack; Sulie L. Chang published in Journal of Neuroimmune Pharmacology (2021).
Abstract Inter-relationships between pain sensitivity, drug reward, and drug misuse are of considerable interest given that many analgesics exhibit misuse potential. Here we studied rats as they underwent a series of pain- and reward-related tests: cutaneous thermal reflex pain, induction and extinction of conditioned place preference to oxycodone (0.56 mg/kg), and finally the impact of neuropathic pain on reflex pain and reinstatement of conditioned place preference. Oxycodone induced a signifi
A qualitative phenomenological study, the lived experiences of clinicians who treat clients using marijuana pre- and post-legalization in California are explored. This study was conducted to better understand the misconceptions associated with user attitudes and beliefs about marijuana use and provide clinicians, researchers, and physicians with information on the overall physical and emotional effects of marijuana use. Since legalization, investigating attitude and belief changes was essential
<b>Objective:</b> Cannabis has been touted for a host of pharmacological and therapeutic effects and users commonly report reduced symptoms of physical and mental health conditions, including anxiety, depression, and chronic pain. While there is existing empirical evidence supporting these effects of cannabis use, little is known about the extent to which these effects result from pharmacological versus expectancy factors. We evaluated the associations between participants' cannabis expectancies
In this, the tenth annual update for the F1000Research Tics collection, we summarize research reports from 2023 on Gilles de la Tourette syndrome and other tic disorders. The authors welcome article suggestions and thoughtful feedback from readers.
Fragile X Syndrome (FXS) presents with a constellation of phenotypes, including trouble regulating emotion and aggressive behaviors, disordered sleep, intellectual impairments, and atypical physical development. Genetic study of the X chromosome revealed that substantial repeat expansion of the 5' end of the gene fragile X messenger ribonucleoprotein 1 (<i>FMR1</i>) promoted DNA methylation and, consequently, silenced expression of <i>FMR1</i>. Further analysis proved that shorter repeat expansi
Antidepressants are among the most used medications in the US, with significant deleterious effects on people’s well-being. At any given time, depression impacts approximately 1 in 10 Americans, causing wide and broad societal costs. Interest is developing for non-pharmacological treatments and preventative measures. We summarize the literature on non-invasive dietary and lifestyle approaches for treating depression. This review aims to inform future research and treatment programs for depressio
Aims: This review aimed to comprehensively examine kratom’s therapeutic potential for treatment of mental health-related issues as well as any related benefits and risks. Design: Systematic review. Data sources: Google Scholar, Web of Science, PubMed, Scopus, PsycINFO, EMBASE, Cochrane Library, and Medline. Review methods: Three authors carried out electronic search of articles published between 1950 to September 2022 through major databases for a duration of three months (from July to September
<b><i>Objective:</i></b> To evaluate the associations between baseline demographics, health conditions, pain management strategies, and health-related quality-of-life (HRQoL) measures with pain management strategies at 3-month follow-up in respondents reporting current low-back pain (LBP). <b><i>Study design:</i></b> Cohort study of survey data collected from adults with LBP sampled from Amazon Mechanical Turk crowdsourcing panel. <b><i>Methods:</i></b> Demographics, health conditions, and the P
Abstract BackgroundDepression is one of the most prevalent mental illnesses in the world today, the onset of depression is usually accompanied by neuroinflammation and neurogenic damage. Recently, G protein coupled receptor 55 (GPR55) has been associated with mood regulation as a third kind of cannabinoid receptor, and the activation of GPR55 was demonstrated recently to have a neuroprotective effect on hippocampal neurogenesis against inflammatory insult. However, its role in regulating depress
Prayer, spirituality, and music are frequently used by patients with mental health disorders and were perceived to be helpful in relieving symptoms. CIM use was not related to SDOH risk factors. Integrating CIM therapies may be beneficial for improving mental health in this population.
Findings highlight the importance of individualized interventions for symptom management or problems related to the use of psychoactive substances. We observed that although somatic symptoms predicted later use of substances, use of substances did not show appreciable effects with regard to alleviating somatic symptoms in people with fibromyalgia.
Background: HIV remains a major burden to the health care system and neuropathic pain is the most common neurological complication of HIV-infection. Since current treatment strategies often lack satisfying pain relief, cannabinoids are discussed as a new option. We investigated Cannabidivarin as treatment for HIV-associated neuropathic pain. Methods: We conducted a randomized, double-blind, placebo-controlled cross-over study. Patients underwent two successive treatment phases (4 weeks each) and