Hemp Research — Page 103

Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.

Promising Health Benefits of Adjuvant Acmella and Zingiber Extracts Combined with Coenzyme Q10 Phytosomes, Supplementation in Chronic Pain Treated with Medical Cannabis: A Prospective and Open-Label Clinical Study (2022)

After 90 days, significant pain relief was detected in almost 70% of the subjects receiving the new dietary supplement, with sensory, emotional, and pain amelioration in one-third of them. A reduction in both tetrahydrocannabinol (THC) and cannabidiol (CBD) doses was also observed after 3 months of supplementation. These findings demonstrate new perspectives for the use of an innovative dietary supplement that combines <i>Acmella</i> and <i>Zingiber</i> extracts, Coenzyme Q10, and group B vitami

Cannabis-Using Youth Demonstrated Blunted Rostral Anterior Cingulate Cortex Activation, but Normal Functional Connectivity, During an Emotional Go/No-Go Task (2019)

Cannabis use has been associated with deficits in self-regulation, including inhibitory control. Cannabis users have previously exhibited both structural and functional deficits in the rostral anterior cingulate cortex (rACC), a region involved in self-regulation of emotional response and inhibitory control. The present study aimed to examine whether abstinent cannabis users demonstrated abnormal functional activation and connectivity of the bilateral rACC during an emotional inhibitory processi

TRASTORNO POR USO USO DE SUSTANCIAS EN PACIENTES CON TRASTORNO DEL ESPECTRO AUSTISTA (2023)

ObjetivosEl lenguaje corporal, como mecanismo de comunicación, de un paciente con patología Dual en consulta, puede suponer más del 50% del impacto percibido, de todos los mensajes transmitidos cara a cara (gestos, posturas, movimientos, respiración,…).La evaluación y actuación del profesional sanitario en lo expuesto anteriormente, así como en manifestaciones de la piel, tatuajes, lesiones y heridas de origen multifactorial, además con implicaciones médico-legales es fundamental, a nivel perici

A Tourette Syndrome/ADHD-like Phenotype Results from Postnatal Disruption of CB1 and CB2 Receptor Signalling (2025)

Cannabinoid receptor 1 (CB<sub>1</sub>) signalling is critical for weight gain and for milk intake in newborn pups. This is important as in humans, low birth weight increases the risk for attention-deficit hyperactivity disorder (ADHD). Moreover, some children with ADHD also have Tourette syndrome (TS). However, it remains unclear if insufficient CB<sub>1</sub> receptor signalling may promote ADHD/TS-like behaviours. Here, ADHD/TS-like behaviours were studied from postnatal to adulthood by expos

Effects of ayahuasca on fear and anxiety: cross-talk between 5HT1A and 5HT2A receptors (2024)

Ayahuasca is a hallucinogenic substance currently being investigated for the treatment of mood, anxiety, and trauma-related disorders. Evidence from animal and human studies suggest that the effects of ayahuasca involve modulation of neural substrates relevant for emotional processing, especially in regions rich in serotonergic receptors. Moreover, preclinical studies also show that ayahuasca has specific effects on fear-related memories. The serotonergic system has been classically associated t

RESULTADOS EN ADICCIONES Y ESTABILIZACIÓN DE DIAGNÓSTICOS EN SALUD MENTAL 2022. HOSPITAL DE DÍA DE SALUD MENTAL Y ADICCIONES DE BAJA EXIGENCIA. CENTRO DE SALUD MENTAL I ADICCIONES DE GRACIA, BARCELONA. HOSPITAL MARE DE DÉU DE LA MERCÈ. (2023)

El lenguaje corporal, como mecanismo de comunicacin, de un paciente con patologa Dual en consulta, puede suponer ms del 50% del impacto percibido, de todos los mensajes transmitidos cara a cara (gestos, posturas, movimientos, respiracin,). La evaluacin y actuacin del profesional sanitario en lo expuesto anteriormente, as como en manifestaciones de la piel, tatuajes, lesiones y heridas de origen multifactorial, adems con implicaciones mdico-legales es fundamental, a nivel pericial, para que el si

Role of the gut-brain axis in HIV and drug abuse-mediated neuroinflammation (2023)

Drug abuse and related disorders are a global public health crisis affecting millions, but to date, limited treatment options are available. Abused drugs include but are not limited to opioids, cocaine, nicotine, methamphetamine, and alcohol. Drug abuse and human immunodeficiency virus-1/acquired immune deficiency syndrome (HIV-1/AIDS) are inextricably linked. Extensive research has been done to understand the effect of prolonged drug use on neuronal signaling networks and gut microbiota. Recent

Assessment of clinical outcomes in patients with inflammatory arthritis: analysis from the UK Medical Cannabis Registry (2024)

The aim of this study was to assess changes in validated patient-reported outcome measures after initiation of cannabis-based medicinal products (CBMPs) and the safety of CBMPs in patients with inflammatory arthritis. A prospective case series from the UK Medical Cannabis Registry was analyzed. The primary outcomes changes were in Brief Pain Inventory, McGill Pain Questionnaire, EuroQol 5-dimension 5-level (EQ-5D-5L), Generalised Anxiety Disorder-7 questionnaire, and Single-Item Sleep Quality Sc

Chronic pain and cognitive dysfunction: clinical manifestations, underlying mechanisms, and emerging therapeutic strategies (2025)

Chronic pain affects up to 60% of the population and not only impairs physical function but also leads to multidimensional neurocognitive deficits, including diminished attention, working memory impairment, and executive dysfunction. Clinical studies indicate that chronic pain induces gray matter atrophy in key brain regions, such as the prefrontal cortex and hippocampus, along with disrupted functional connectivity and other pathological alterations. Despite extensive research, the precise path

Expectancies of the Effects of Cannabis Use in Individuals with Social Anxiety Disorder (SAD) (2024)

Previous research has indicated that anticipating positive effects from cannabis use may be linked with increased frequency of cannabis consumption, yet these expectancies remain poorly understood in adults with social anxiety disorder (SAD). Thus, our study aimed to investigate the expectancies of the effects of cannabis use in 26 frequently using adults with SAD (age: 27.9 ± 7.3 years; 54% female) and 26 (age: 27.4 ± 6.7 years; 50% female) without. While no between-group differences were obser

Perturbation of 3D nuclear architecture, epigenomic aging and dysregulation, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 2—Metabolome, immunome, synaptome (2023)

The second part of this paper builds upon and expands the epigenomic-aging perspective presented in Part 1 to describe the metabolomic and immunomic bases of the epigenomic-aging changes and then considers in some detail the application of these insights to neurotoxicity, neuronal epigenotoxicity, and synaptopathy. Cannabinoids are well-known to have bidirectional immunomodulatory activities on numerous parts of the immune system. Immune perturbations are well-known to impact the aging process,

The Endocannabinoid System in the Development and Treatment of Obesity: Searching for New Ideas (2025)

Obesity is a complex, multifactorial disease and a growing global health challenge associated with type 2 diabetes, cardiovascular disorders, cancer, and reduced quality of life. The existing pharmacological therapies are characterized by their limited number and efficacy, and safety concerns further restrict their utilization. This review synthesizes extensive knowledge regarding the role of the endocannabinoid system (ECS) in the pathogenesis of obesity, as well as its potential as a therapeut

Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic review (2025)

Endometriosis (EMs) is a prevalent benign gynecological disorder characterized by dysmenorrhea and infertility, significantly impacting women's health and quality of life. Currently, the pathogenesis of EMs remains incompletely elucidated. There are various side effects of drug treatment, while surgical interventions involve a certain degree of tissue trauma. Therefore, novel therapeutic drugs and clinical strategies should be developed. Apoptosis, a programmed cell death pathway, maintains tiss

EXPLORING THE EFFICACY AND SAFETY OF CANNABIS IN THE MANAGEMENT OF FIBROMYALGIA (2022)

Fibromyalgia is a chronic health condition characterized by chronic pain fatigue, sleep disturbances and many other symptoms affecting a patient’s quality of life. Patients with fibromyalgia often visit rheumatology outpatients with a long list of symptoms and often receive multiple medications. Many have seen multiple specialists and have done a lot of reading about alternative modalities of treatment. The limited effectiveness of conventional therapy coupled with widespread media attention rai

Prevalence, psychiatric correlates, and psychosocial determinants of illicit substance use among UK undergraduate students (2022)

Abstract This study examined the prevalence of illegal drug use in UK students and motivators behind such behaviour. Additionally, we explored possible relationships between substance use, psychosocial motivators, and psychiatric distress. N=543 students completed online measures of substance use, anxiety, depression, perceived stress, insomnia. A series of reasons behind their use were ranked based on importance. Reported cannabis, cocaine, nitrous oxide, ketamine and MDMA use were most prevale