Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
The maintenance of homeostasis in the gastrointestinal (GI) tract is ensured by the presence of the endocannabinoid system (ECS), which regulates important physiological activities, such as motility, permeability, fluid secretion, immunity, and visceral pain sensation. Beside its direct effects on the GI system, the ECS in the central nervous system indirectly regulates GI functions, such as food intake and energy balance. Mounting evidence suggests that the ECS may play an important role in mod
The effects of cannabis use on the brain, mind, and body have been studied for decades. The developing brain, particularly the adolescent and young adult brain, undergoes critical development that makes it especially susceptible to the effects of cannabis use. Among the adverse effects of cannabis use in adolescence and young adulthood, psychosis and psychotic disorders (e.g., schizophrenia) have been examined. The association of cannabis use with schizophrenia was first elucidated in a Swedish
The results of this analysis suggest that individuals with comorbid TBI and CUD may be at increased risk for early onset cognitive disorders, including dementia.
Peer-reviewed industrial hemp research by Jennifer Spohrs; Valentin Kühnle; Stefan O. Reber; David Mikusky; Niklas Sanhüter; Ana Macchia; Sandra Nickel; Birgit Abler published in Psychopharmacology (2025).
We are amidst a global addiction crisis, yet stigmas surrounding addiction counterintuitively prevail. Understanding and appreciating the neurobiology of addiction is essential to dissolve this stigma and for the development of new pharmacological agents to improve upon currently narrow therapeutic options. This review highlights this and evaluates dopamine-and-cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32) as a potential target to treat various forms of substance abuse. Despite the proven
We studied the effect of marijuana liberalization policies on perinatal health with a multiperiod difference-in-differences estimator that exploited variation in effective dates of medical marijuana laws (MML) and recreational marijuana laws (RML). We found that the proportion of maternal hospitalizations with marijuana use disorder increased by 23% (0.3 percentage points) in the first three years after RML implementation, with larger effects in states authorizing commercial sales of marijuana.
Gambling disorder and cannabis use disorder are both considered major public health issues. Despite the well-documented frequency of substance use disorders among people with gambling disorder, little is known about the experiences of those who both engage with gambling and cannabis. A scoping review was undertaken to investigate studies focusing on the experiences of people who gamble and use cannabis. Unexpectedly, no qualitative or mixed-methods studies that included an in-depth qualitative c
This is the largest study to date to document cannabis product usage patterns and perceived benefits for migraine management in a clinical headache patient sample. A majority of patients surveyed reported using cannabis products for migraine management and cited perceived improvements in migraine characteristics, clinical features, and associated risk factors. The findings warrant experimental trials to confirm the perceived benefits of cannabis products for migraine prevention and treatment.
Stress may play a role in the performance of occupational therapy students during Level II fieldwork, but little research exists regarding the causes of stress or the stress management strategies students use. The objective of this study was to determine factors that contribute to fieldwork-related stress and strategies students use to manage that stress on Level II fieldwork. Students or recent graduates of occupational therapy or occupational therapy assistant programs who completed at least o
The COVID-19 pandemic, caused by SARS-CoV-2, is a deadly disease affecting millions due to the non-availability of drugs and vaccines. The majority of COVID-19 drugs have been repurposed based on antiviral, immunomodulatory, and antibiotic potential. The pathogenesis and advanced complications with infection involve the immune-inflammatory cascade. Therefore, a therapeutic strategy could reduce infectivity, inflammation, and immune modulation. In recent years, modulating the endocannabinoid syst
Fragile X syndrome (FXS) is a genetic disorder caused by a mutation in the <i>FMR1</i> gene on the X chromosome, leading to a range of developmental and intellectual disabilities. FXS is characterized by intellectual disability, behavior challenges, and distinct physical features such as an elongated face, large ears, and hyperflexible joints; FXS remains the most common inherited cause of intellectual disability. Behavioral manifestations often include attention deficits, hyperactivity, anxiety
Public perception contrasts scientific findings on the depression-related effects of cannabis. However, earlier studies were performed when cannabis was predominantly illegal, its production was mostly uncontrolled, and the idea of medical cannabis was incipient only. We hypothesized that recent changes in attitudes and legislations may have favorably affected research. In addition, publication bias against cannabis may have also decreased. To investigate this hypothesis, we conducted a review o
Cannabis use, including among pregnant women, has increased in recent years due to legalization and other factors in several countries. Cannabidiol (CBD), one of Cannabis' main constituents, is often seen as a natural and safe substance and increasingly used for treating medical conditions such as pain, anxiety, and depression. Women report using CBD during pregnancy to alleviate pregnancy-related symptoms such as nausea, vomiting, and chronic pain. However, few studies exist in the literature r
The amygdala is composed of several nuclei, including the lateral nucleus which is the main receiving area for the input from cortical and subcortical brain regions. It mediates fear, anxiety, stress, and pain across species. Evidence suggests that the endocannabinoid system may be a promising target for modulating these processes. Cannabinoid and cannabinoid-related receptors have been identified in the amygdala of rodents, carnivores, and humans, but not in horses. This study aimed to investig
Introduction: The legalization of cannabis across Canada in October 2018 introduced issues including regulation at different levels, public and individual education, and discussions about cannabis product safety. We aimed to discuss ineffective and effective cannabis use policy on campuses and associated public areas, given the known short-term and long-term effects pertaining to its neurologic, pulmonary, and purported medicinal effects. Cannabis interferes with many of the body’s basic and exe
Peer-reviewed industrial hemp research by Ana Canseco-Alba; Koichi Tabata; Yukihiko Momoki; T Tabassum; Yasue Horiuchi; Tadao Arinami; Emmanuel S. Onaivi; Hiroki Ishiguro published in Progress in Neuro-Psychopharmacology and Biological Psychiatry (2023).
In the past decade, the use of cannabidiol (CBD) has greatly increased in the United States. The Agricultural Improvement Act of 2018 legalized hemp-derived products in all 50 states, contributing to the continued growth of cannabidiol use and the first FDA approved cannabidiol product, Epidiolex.1, 2 Cannabidiol is used to treat a variety of symptoms including anxiety, depression, chronic pain, insomnia, and poor appetite; and is commonly used in people with cystic fibrosis (PwCF).3 Approximate
Previous research on the relationship between cannabis and posttraumatic stress disorder (PTSD) has produced equivocal results. One explanation is that differences in cannabis use characteristics (e.g., medicinal vs. recreational use, route of administration, THC to CBD ratio, and grams per day) are associated with differences in PTSD severity. Using data from a previous cross-sectional study, we performed a series of MANOVAs to examine how cannabis use, cannabis use characteristics, sex, and ta
Future research needs to investigate commonly used but less evaluated products (e.g. chamomile, St John's Wort) and to evaluate products against or alongside conventional treatments to better reflect patient decision making.
Higher odds of clinically significant PTSD, depression, anxiety, and poor sleep quality are present in people with traumatic brain injury (TBI) who misuse opiates and/or who use marijuana regularly. In the absence of opiate misuse, regular marijuana use had higher odds of worse behavioral health outcomes than occasional and no use. The interaction of opiate misuse and regular marijuana use yielded the highest odds. Individuals with TBI should be informed of the relationship of substance use and
Peer-reviewed industrial hemp research by Timothy Leroux; Prabjit Ajrawat; Kala Sundararajan; Naomi Maldonado-Rodriguez; Bheeshma Ravi; Rajiv Gandhi; Y. Raja Rampersaud; Christian Veillette; Nizar N. Mahomed; Hance Clarke published in Journal of Cannabis Research (2024).
Results indicate that both men and individuals from minoritized racial and ethnic groups are more likely to report heightened PTSD symptomology, maladaptive coping, and worsening symptoms. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Peer-reviewed industrial hemp research by Reza Moshfeghinia; Bahare Oji; Mehrnaz Hosseinzadeh; Mohammad Pourfridoni; Jamshid Ahmadi published in BMC Psychiatry (2023).
Our review outlined that few studies considered chronic diseases as a whole and that few patients are involved in the co-construction of data collection tools as well. There is an evidence gap concerning the results in terms of methodological quality when engaging patients in their design. Future research should evaluate why cannabis' effectiveness varies between patients, and how access affects the decision to use or not to use MC, particularly regarding the relationship between patients and he
Abstract Background Legalization of cannabis for medical uses has proceeded without well-controlled studies. Real world patterns of medical cannabis use are highly variable and rarely overseen by a physician. Smartphone assessments that capture ecologically valid patterns of medical cannabis use and health symptoms may help clarify risks and benefits. Methods As part of a larger, randomized trial ( NCT03224468 ), adults (N=181) seeking cannabis for insomnia, pain, or anxiety or depressive sympto