Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
The case adds to the evidence suggesting that Δ<sup>9</sup>-THCP is highly potent and psychoactive. Even experienced users of THC may have adverse effects to Δ<sup>9</sup>-THCP due to differences in binding and potency. Isolates of phytocannabinoids require caution prior to use.
<b>Introduction:</b> Cannabis use is associated with brain functional changes in regions implicated in prominent neuroscientific theories of addiction. Emerging evidence suggests that cannabidiol (CBD) is neuroprotective and may reverse structural brain changes associated with prolonged heavy cannabis use. In this study, we examine how an ∼10-week exposure of CBD in cannabis users affected resting-state functional connectivity in brain regions functionally altered by cannabis use. <b>Materials a
The endocannabinoid system has been implicated in both social and cognitive processing. The endocannabinoid metabolism inhibitor, URB597, dose-dependently improves non-social memory in adult Wistar and Sprague Dawley rats, whereas its effect on social interaction (SI) is affected by both rat strain and drug dose. Lister Hooded rats consistently respond differently to drug treatment in general compared with albino strains. This study sought to investigate the effects of different doses of URB597
Ebola virus disease (EVD) remains a significant public health threat, with sporadic outbreaks occurring in Sub-Saharan Africa. Survivors of EVD may experience various post-infection symptoms, collectively known as post-Ebola virus syndrome (PES), which include chronic arthralgia, uveitis, headache, and psychosocial stressors. In this review, we discuss the persistence of Ebola virus in survivors and its possible role in the reemergence of current outbreaks. We highlight that waning immunity of s
Using ecological momentary assessment (EMA), we assessed momentary patterns of alcohol and cannabis co-use in college students and whether state-level and baseline reports of anxiety varied based on type of substance(s) consumed. Students (<i>N</i>=109) reporting regular cannabis use completed a baseline assessment and two-week signal-contingent EMA, with three random prompts/day. At each EMA instance, we categorized instances of substance "usage" as: 1) no use, 2) cannabis-only, 3) alcohol-only
ABSTRACT The objective of this randomized, double-blinded controlled trial was to evaluate the safety and relative effects of different formulations containing Cannabidiol (CBD) and melatonin, with and without the addition of minor cannabinoids, on sleep. Participants (N=1,793 adults experiencing symptoms of sleep disturbance) were assigned to receive a 4-week supply of 1 of 6 products (all capsules) containing either 15mg CBD or 5mg melatonin, alone or in combination with minor cannabinoids. Sl
These findings underscore the importance of conducting high-quality clinical trials that include diverse pain populations and clinically relevant outcomes that if successful, could support FDA approval of cannabinoid products. Clinicians could then prescribe and monitor these treatments similarly to other chronic pain medications.
Peer-reviewed industrial hemp research by Matthew Murphy; Varinder Kaur; Hanh Lan Bui; Toby Yang; Simon Erridge; Carl Holvey; Ross Coomber; James Rucker; Mark Weatherall; Mikael H. Sodergren published in Multiple Sclerosis and Related Disorders (2024).
Cannabis consumption and legalization is increasing globally, raising concerns about its impact on fertility. In humans, we previously demonstrated that tetrahydrocannabinol (THC) and its metabolites reach the ovarian follicle. An extensive body of literature describes THC's impact on sperm, however no such studies have determined its effects on the oocyte. Herein, we investigate the impact of THC on human female fertility through both a clinical and in vitro analysis. In a case-control study, w
Peer-reviewed industrial hemp research by Krusha V. Patel; Alysia B. G. Hunt; Juan Castillo‐Fernandez; Christine Abrams; Tammie King; Phillip Watson; Gregory C. A. Amos published in Scientific Reports (2024).
Prenatal Δ9-tetrahydrocannabinol exposure (PTE) poses long-lasting neuropsychiatric risks, as evidenced by clinical and preclinical studies, yet the neurobiological mechanisms remain poorly defined. Emerging evidence implicates the neurolipidome, a critical mediator of neurodevelopment and endocannabinoid signaling, as a potential contributor. Here, we demonstrate that dietary omega-3 fatty acid supplementation sex-selectively ameliorates neurodevelopmental deficits induced by PTE in a Wistar ra
Peer-reviewed industrial hemp research by Reena Sheth; Esha Parikh; Kunmilayo Olayeye; Kylie Pfeifer; Deepesh Khanna published in Cureus (2024).
Peer-reviewed industrial hemp research by Andrea Sixto-Costoya; Carlos García-Zorita; Juan Carlos Valderrama‐Zurián; Elías Sanz Casado; Antonio Eleazar Serrano-López published in International Journal of Mental Health and Addiction (2023).
Cannabis users have been historically stigmatized and criminalized for non-violent behaviors such as consuming, producing, and distributing cannabis. Racialized cannabis users in particular have been constructed as fundamentally different, dangerous, and mentally unstable, while state actors have benefited from the subjugation of this group. The following article reviews the history of cannabis prohibition with an emphasis on the social construction of racialized cannabis users and role of socia
Cannabinoids, particularly Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), have gained popularity as alternative sleep aids; however, their effects on sleep architecture and next-day function remain poorly understood. Here, in a pilot trial, we examined the effects of a single oral dose containing 10 mg THC and 200 mg CBD (THC/CBD) on objective sleep outcomes and next-day alertness using 256-channel high-density EEG in 20 patients with DSM-5 diagnosed insomnia disorder (16 female; mean (SD)
Cannabis plant is increasingly becoming a topic of public discussion. All efforts by United Nations Single Convention on Narcotic Drugs (UNODC) have triggered a major obstacle for cannabis to be seen for its medicinal potentials. However, over the years, illegal cannabis consumption has grown making users’ cannabis dependent. Cannabis dependency affects the users’ brain and body, initiating side effects which pose risk of survival, attacking the Central Nervous System, responsible for sanity and
Posttraumatic stress disorder is often treatment-resistant and recent research has suggested that treatment outcomes might be improved by modulation of the endocannabinoid system. The current review article describes animal and human research examining the effect of endocannabinoid modulation on posttraumatic symptoms, behaviours, and relevant memory processes. While the preclinical literature is reasonably consistent, emerging human literature is mixed. This review explores some potential reaso
Our results allow one to select the stressful events to which, in the pandemic era, it is necessary to pay particular attention in a clinical setting and suggest the implementation of psychological interventions that make emotion regulation an essential direct target of treatment in chronic stress-related pathology such as anxiety disorders.
This review explores the antidepressant effects of ginsenoside Rb1, a natural compound in traditional Chinese medicine, and its potential for treating major depressive disorder (MDD). The aetiology of depression was reviewed up to 2024, focusing on the pathways and mechanisms through which ginsenoside Rb1 may exert its effects. Notably, ginsenoside Rb1 regulates oxidative stress and inflammatory processes while enhancing neural plasticity by downregulating miR-134 expression and alleviating depr
EudraCT 2021-004868-95; NCT05809414.
The mesolimbic reward system originating from dopamine neurons in the ventral tegmental area (VTA) of the midbrain shows a profound reduction in function during cannabinoid withdrawal. This condition may underlie aversive states that lead to compulsive drug seeking and relapse. The lateral habenula (LHb) exerts negative control over the VTA via the GABA rostromedial tegmental nucleus (RMTg), representing a potential convergence point for drug-induced opponent processes. We hypothesized that the
This trial suggests rTMS is safe and feasible in individuals with CUD and may have a therapeutic effect on frequency of cannabis use, though further study is needed with additional rTMS-sessions and a longer follow-up period.
Peer-reviewed industrial hemp research by Carsten Hjorthøj; Christine Merrild Posselt published in The Lancet Psychiatry (2020).
The current studies are still inadequate in terms of comparability due to their heterogeneity, cue-reactivity can be conducted in the future by constructing a standard library of smoking cue materials. Causal analysis is suggested in order to adequately screen for causes of addiction persistence, and further explore the specific objective cue-reactivity-related indicators of TUD.
Psychiatric disorders are a major cause of illness in the world. Unfortunately, many patients are resistant to treatment and present serious complications. Schizophrenia is refractory to treatment in about one-third of patients. Antidepressants are effective in about half of patients. Suicidal ideation is an increasing issue in patients with mixed features in bipolar disorder (BD). Therefore, there is a need to develop and test new drugs or new indications of available medications for the treatm