Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
Peer-reviewed industrial hemp research by Anne Richards; Jennifer C. Kanady; Thomas C. Neylan published in Neuropsychopharmacology (2019).
Peer-reviewed industrial hemp research by Anna-Chiara Schaub; Else Schneider; Jorge F. Vázquez‐Castellanos; Nina Schweinfurth; Cedric Kettelhack; Jessica P. K. Doll; Gulnara Yamanbaeva; Laura Mählmann; Serge Brand; Christoph Beglinger published in Translational Psychiatry (2022).
Although the etiology and expression of psychiatric disorders are complex, mammals show biologically preserved behavioral and neurobiological responses to valent stimuli which underlie the use of rodent models of post-traumatic stress disorder (PTSD). PTSD is a complex phenotype that is difficult to model in rodents because it is diagnosed by patient interview and influenced by both environmental and genetic factors. However, given that PTSD results from traumatic experiences, rodent models can
Determinants of anxiety in elite populations broadly reflect those experienced by the general population. Clinicians should be aware of these general and athlete-specific determinants of anxiety among elite athletes.
Although individual-level risk remains moderate to low and results from this study should be confirmed in future adequately powered prospective studies, the high prevalence of adolescents consuming cannabis generates a large number of young people who could develop depression and suicidality attributable to cannabis. This is an important public health problem and concern, which should be properly addressed by health care policy.
Botanicals and herbs have been used by people with epilepsy for ages in various cultures across the world. Patients in both developing and developed nations are currently using herbal remedies to manage seizures or side effects from antiepileptic medicines (AEDs). The deleterious effects of AED medication have a greater impact on the patient’s life than seizures. Alternative remedies should be used to treat and manage epilepsy because synthetic pharmaceuticals have risks. Epilepsy may be managed
Abstract Sodium channel inhibitors are used to treat neurological disorders of hyperexcitability. However, all currently available sodium channel targeting anti-seizure medications are non-selective among the Na V isoforms which potentially limits efficacy and therapeutic safety margins. XPC-7724 and XPC-5462 represent a new class of small molecule compounds. These compounds target inhibition of the Na V 1.6 and Na V 1.2 channels in excitatory pyramidal neurons and possess a molecular selectivit
Background: Drug-resistant epilepsy (DRE) is a condition that affects up to 40% of the total population of patients with epilepsy. Advancements in the pharmaceutical field over recent decades have facilitated a significant expansion in the range of available drug options. Nevertheless, the prevalence of DRE has remained unaltered in recent years. Areas of Uncertainty: It is not completely understood how the new antiseizure medications and therapeutic strategies will impact the current burden of
Background: Acute Flaccid Paralysis or polio is a viral infectious disease that affects the motor neurons of the central nervous system and can be prevented through vaccination.
It appears that the delta frequency plays a pivotal role in modulating the corticothalamic network during seizures. Our results underscore the significance of comprehending the spatiotemporal dynamics of the corticothalamic network during seizures, and this knowledge could guide personalized neuromodulation treatment strategies.
The prevention of human immunodeficiency virus (HIV) infection has recently emphasized the use of pre- and post-exposure prophylaxis (PrEP and PEP), both of which were highly effective in prevention of HIV infection. Since the last published guidance regarding the cotreatment of people with anti-seizure medications (ASM) and antiretroviral treatments (ARTs) in 2012, both fields have numerous new medication options. Historically, cotreatment of HIV and seizures could be challenging with increased
Leonotis leonurusL. R. Br. (Lamiaceae) is a medicinal plant native to the South Africancontinent also employed as a recreational drug and a substitute to Cannabis sativaL. (Cannabaceae). Given the interest of the last mentioned species as a source of treatments for epilepsy among many other pathologies and its possible substitution for L. leonurus, the aim of this article is obtain anatomical and micrographical characters for its identification in chopped or powdered material and to survey the u
Cannabinoid and serotonin systems regulate many biological processes. The aim of the present study was to investigate the functional interaction between the cannabinoid and serotonergic systems of the primary somatosensory region (S1) of the brain in epileptiform activity caused by penicillin. The ACEA (an agonist of CB1 receptor), AM‑251 (an antagonist of CB1 receptor), 8‑OH‑DPAT (an agonist of 5‑HT1A receptor) and WAY‑100635 (an antagonist of 5‑HT1A receptor) were administered into the S1 afte
EDITORIAL article Front. Vet. Sci., 17 May 2023Sec. Veterinary Neurology and Neurosurgery Volume 10 - 2023 | https://doi.org/10.3389/fvets.2023.1200311
Case presentation: A previously healthy 3-year-old boy presented with difficulty understanding commands and developed impairment of spoken language that lasted four months and remitted spontaneously. After 10 months, he suffered again language regression. Electroencephalogram (EEG) revealed electrical status epilepticus during sleep (ESES). He was treated with sulthiame, sodium valproate and clobazam with partial improvement. One year later, after an episode of COVID-19 infection, symptoms worse
Alterations in the extracellular matrix (ECM) are common in epilepsy, yet whether they are cause or consequence of disease is unknow. Using Theiler's virus infection model of acquired epilepsy we find <i>de novo</i> expression of chondroitin sulfate proteoglycans (CSPGs), a major ECM component, in dentate gyrus (DG) and amygdala exclusively in mice with seizures. Preventing synthesis of CSPGs specifically in DG and amygdala by deletion of major CSPG aggrecan reduced seizure burden. Patch-clamp r
This research report examines past research studies on marijuana therapy interventions involving individuals who have Autism Spectrum Disorder, Epilepsy, and Tourette’s Syndrome. These results do not ensure marijuana as a permanent method to cure adverse symptoms for these vulnerable populations. However, these large-scale studies have shown a trend of marijuana being effective for some participants involved in decreasing and/or improving their symptom frequency. This report will contribute to t
Adolescent marijuana use is a significant public health concern given that many individuals first begin using during this developmental period and an earlier age of onset is prospectively associated with numerous marijuana misuse outcomes. The outbreak of COVID-19 has resulted in stay-at-home orders and social distancing guidelines across the United States. For many adolescents, these orders resulted in a number of changes that could alter one’s marijuana use including changes to marijuana avail
Reduced number of dentate PV+ interneurons in TLE micePersistently reduced action potential firing rates of dentate PV+ interneurons in TLE miceEnhanced amplitude but decreased frequency of spontaneous IPSCs in the dentate gyrus in TLE miceIncreased amplitude of evoked IPSCs mediated by dentate PV+ interneurons in TLE miceChemogenetic activation of PV+ interneurons prevents epileptiform activity in TLE mice.
Although prevalence and incidence of LGS in Taiwan were lower than in other countries, the multifaceted burden of illness in LGS is highlighted herein. Reduced hospitalizations through better epilepsy control may reduce LGS expenditure.
La nanomedicina es el nombre que se asigna a las tecnologías nanométricas aplicadas al cuidado de la salud, las cuales han permitido el desarrollo de estrategias innovadoras para el tratamiento y diagnóstico de diversas enfermedades, incluidas aquellas que afectan al sistema nervioso central. En particular, debido a las ventajas conferidas por sus características intrínsecas, las nanomedicinas se han explorado como una posible alternativa terapéutica que permita optimizar el control de las crisi
Clinical publications on this morbid condition report as many as 16 different Nav1 7 channel substitutions. They also report more than 40 pharmacological treatments, including agents with sodium channel blocking but nonspecific activity (mexiletine, lidocaine, carbamazepine), anti-neuropathic drugs (gabapentinoids and antidepressants), antidepressant drugs with efficacy on migraines (amitriptyline) vasoactive drugs for the management of hypertension, and analgesics (opioids and ketamine). Curren
Our findings are consistent with previous reports linking structural variants to functional disruption, suggesting impaired Nav channel activity due to a shift in inactivation to hyperpolarized potential, leading to a loss-of-function effect. These findings underscore the utility of LRS for DNA and cDNA analysis in resolving structural variants and expanding the electroclinical spectrum of patients with FGF12 duplications.
Abstract In epilepsy, early diagnosis, accurate determination of epilepsy type, proper selection of anti-seizure treatment, and monitoring; all are essential. However, despite recent therapeutic advances and conceptual reconsiderations in the classification and management of epilepsy, serious gaps are still encountered in day-to-day practice in Egypt as well as several other limited resources countries. Premature mortality, poor quality of life, disabilities, diminished family function, cognitiv
<b>Background:</b> Third generation antiseizure medications (ASMs) are currently used for seizure control as well as several other indications, including pain management and psychiatric disorders. As a result, maternal exposure to third generation ASMs during pregnancy has become increasingly prevalent. The current systematic review aimed to summarize the published evidence on third generation ASMs and their effect on preterm birth, cesarean section (c-section) and fetal loss. <b>Methods:</b> Th