Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
A coletânea é dedicada a estudantes da área da saúde, profissionais de saúde, residentes em saúde, gestores e especialistas que desejem aprofundar conhecimentos em suas áreas e fora de sua especialidade. Os autores brasileiros trazem um pouco do cenário nacional em pesquisa e saúde, através de artigos que apresentam abordagens de interesse das várias profissões de saúde, e assim, pretende inspirar os leitores a contribuírem com estudos voltados para a atenção à saúde, a promoção de saú
E-cigarettes gained popularity globally through the promotion of e-cigarettes as a risk-free way to stop traditional smoking. However, new evidence suggests that they may have a detrimental effect on the nervous system and ultimately adverse neurological manifestations. Seizures have been reported among both new and experienced e-cigarette users. In several cases, the seizure presented immediately after its use, while others reported continuous use for weeks before seizures occurred. This review
Mutations in TSC1 or TSC2 in axons induce tuberous sclerosis complex. Neurological manifestations mainly include epilepsy and autism spectrum disorder (ASD). ASD is the presenting symptom (25-50% of patients). ASD was observed at significantly higher frequencies in participants with TSC2 than those with TSC1 mutations. The occurrence of TSC2 mutations is about 50% larger than TSC1. Therefore, ASD may develop due to TSC2 deficiency. TSC2 regulates microRNA biogenesis and Microprocessor activity v
ABSTRACT Objective We identified a novel de novo SCN2A variant (M1879T) associated with infantile-onset epilepsy that responded dramatically to sodium channel blocker antiepileptic drugs. We analyzed the functional and pharmacological consequences of this variant to establish pathogenicity, and to correlate genotype with phenotype and clinical drug response. Methods The clinical and genetic features of an infant boy with epilepsy are presented. We investigated the effect of the variant using het
Local anesthetics are commonly deployed for a variety of medical procedures across many disciplines. Systemic toxicity is rarely seen in clinical practice, and quick recognition and how to manage this syndrome are crucial. The development of systemic toxicity is influenced by the site of administration, the type of anesthetic used, and the total dose administered. Local anesthetic systemic toxicity (LAST) syndrome is used as a diagnosis to encompass the cardiovascular and pulmonary adverse effec
The importance of sleep has been reported for decades. Epilepsy is a heterogeneous disorder comprising multiple elements that might influence sleep and wakefulness. Notably, animal studies show disruptions of the circadian molecular system in different models of epilepsy, along with altered rest-activity and other circadian rhythms. So far, studies of molecular circadian systems in people with epilepsy are lacking, prompting further research. Seizures-the primary and most debilitating symptom of
Oxidative stress and apoptosis cell death are critical secondary damage mechanisms that lead to losing neighboring healthy tissue after cerebral ischemia. This study aims to characterize the type of interaction between dapsone (DDS) and cannabidiol (CBD) and its cytoprotective effect in an in vitro model of oxygen and glucose deprivation for 6 h followed by 24 h of reoxygenation (OGD/R), using the SH-SY5Y cell line. For the combined concentrations, an isobolographic study was designed to determi
The importance of diligent consultation, the consideration of novel methods such as parent/patient preference trials and/or discrete choice experiments in studies examining the effectiveness of ASMs versus no-ASMs cannot be overemphasised even in the presence of widespread clinician equipoise.
Use of hemp-derived products are associated with adverse drug reactions, including serious neurological and psychiatric events, with marked heterogeneity by age and gender.
About 1/3 of patients with epilepsy continue to experience seizures despite treatment with antiepileptic drugs. Variability in drug concentrations after intake of a given dose, so-called pharmacokinetic variability, contributes to differences in response. Therapeutic drug monitoring by measurement of serum concentrations combined with clinical interpretation of the results can be used to adjust for such variability, and is a tool to individualize and optimize treatment.\n\nThe thesis aimed to co
Peer-reviewed industrial hemp research by O Devinsky; A Patel; J Cross; V Villanueva; E Wirrell; M Privitera; E Thiele; E Marsh; J French; M Mazurkiewicz-Beldzinska published in Australian Prescriber (2020).
Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease-targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second-generation drug candidates that may be of interest beyond selected DEEs. Although the first group of approaches can only be tested in dedicated DEE models, assessment in induced non-s
Introduction The good and bad news regarding better health care for patients with epilepsy lie in the advances of research on the background of the negative impact of global challenges that are beyond the control of clinicians and researchers. Epilepsy and climate change Climate change as an important environmental variable in the generation and exacerbation of epilepsy can no longer be ignored (1). Consequences of climate change include more frequent and intense heatwaves and natural disasters
Certain foods and specific drugs have been linked to epilepsy in the literature. Here, we query PubMed citations for the co-occurrence of epilepsy with foods and drugs, using a list of 217,776 molecules from the HMDB. Notably, the top associations with epilepsy include approved drugs and drug families, diagnostic markers, inducers, and vitamins. Drugs include fosphenytoin (40%), topiramate (37%), valproic acid (34%), hydantoin (20%), phenytoin (31%), carbamazepine (33%), carbamazepine-10,11-epox
Peer-reviewed industrial hemp research by Luca Bergonzini; Davide Leardini; Roberta Rao; Thomas Foiadelli; Maura Faraci; Maria Margherita Mancardi; Giulia Nobile; Alessandro Orsini; Salvatore Savasta; Francesca Gottardi published in Seizure (2024).
In recent years, molecular genetics has rapidly developed in Poland, along with a steady increase in knowledge of Dravet syndrome among the medical profession. Early and precise diagnosis provides the opportunity to target treatment with drugs dedicated to Dravet syndrome with high efficacy.
O Transtorno do Espectro Autista é um distúrbio do neurodesenvolvimento, heterogêneo e de forte componente genético. Possui alta prevalência de comorbidades psiquiátricas, explicada tanto por mecanismos fisiopatológicos semelhantes quanto por sobreposição de sintomas e fatores externos, questões que podem tanto dificultar o diagnóstico da associação quando gerar mecanismo agravante entre os distúrbios. Recentemente, órgãos americanos aprovaram o uso do canabidiol para tratamento de encefalopatia
Angelman syndrome (AS) is a rare neurogenetic disorder characterized by developmental delay, epileptic seizures, cognitive impairment, electroencephalographic epileptiform and slow interictal abnormalities, and motor dysfunction.1 In AS, nonconvulsive status epilepticus (NCSE) is frequent, is characterized by period of decreased responsiveness which may last hours to days, and it occur in about 20% of patients.2 Treatment of NCSE in AS is challenging and no specific drugs are approved with this
BACKGROUND AND OBJECTIVES: Evidence has revealed an important role in the use of medical cannabis, and the interaction of the endocannabinoid system with other drugs for the treatment of chronic neuropathic and nociplastic pain. The objective of this review is to bring an update on published data on doses and care with the use of cannabinoids that demonstrate the interaction in the pathophysiology of chronic pain and its treatment. CONTENTS: A research-based review was carried out in the MEDLINE
Thrombocytopenia is one of the side effects of VPA. This study aimed to evaluate the incidence and risk factors of thrombocytopenia after intravenous VPA treatment in children with neurosurgical operations. Pediatric patients undergoing neurosurgical operations treated with intravenous VPA were enrolled in this retrospective study. According to platelet count after intravenous injection of VPA, the pediatric patients were divided into the thrombocytopenia group and the non-thrombocytopenia group
Traumatic brain injuries (TBI) are diverse with heterogeneous injury pathologies, which creates challenges for the clinical treatment and prevention of secondary pathologies such as post-traumatic epilepsy and subsequent dementias. To develop pharmacological strategies that treat TBI and prevent complications, animal models must capture the spectrum of TBI severity to better understand pathophysiological events that occur during and after injury. To address such issues, we improved upon our rece