Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
Epilepsy is one of the most prevalent chronic neurological illnesses. Presently, the provision of symptomatic medicine is the treatment method for epilepsy. The majority of patients can attain seizure independence during the first two medication trials. Therefore, pharmaco-resistant individuals are those who cannot get an adequate therapeutic response. However, the range of efficacy, safety, and tolerability, the diversity of seizures and epilepsies, the frequency of comorbidity, and tolerance a
GBP1F induced a mild suppression of locomotor activity, ameliorated anxiety and depression-like behavior, did not alter cognitive behavior, and raised serotonin and 5-HIAA concentrations in the hippocampus and striatum. GBP1F also positively enhanced dopamine and vitamin C tissue levels in the striatum. Thus, GBP1F represents a compound with anxiolytic- and antidepressant-like effects though further studies are warranted at the molecular level to focus on the precise mechanism(s) of action.
The safety profile and initial clinical improvement support the continued development of zorevunersen as a potential disease-modifying treatment for Dravet syndrome. (Supported by Stoke Therapeutics; MONARCH and SWALLOWTAIL ClinicalTrials.gov numbers, NCT04442295 and NCT04740476, respectively; ADMIRAL and LONGWING ISRCTN Registry numbers, ISRCTN99651026 and ISRCTN12811235, respectively.).
Peer-reviewed industrial hemp research by Jennifer H. Yang; Nicholas Scanlon; Wonhee Woo; Jamie Nicole LaBuzetta; Cynthia Gonzalez; Lori Broderick; Taylor A. Doherty; Marc A. Riedl; Anastasie Dunn‐Pirio published in Cureus (2023).
Overall, evidence for direct and long-term adverse effects of cannabis use is minimal and additional longitudinal studies will be required to better delineate unidentified effects.
Self-reported knowledge of THC and CBD concentration statistically differed according to MOD, source of acquisition, source of instruction, and current cannabis use.
Autism spectrum disorder (ASD) is characterized by deficits in communication, social interaction, and repetitive and stereotyped behaviors, with no specific drug therapy available. Studies have found that cannabidiol (CBD) can improve hyperactive and cognitive symptoms in children with ASD. However, little is known about the effect of CBD in combination with other medications, such as risperidone (RISP). This study aimed to evaluate the behavioral and biochemical effects of CBD in animals using
Peer-reviewed industrial hemp research by Amanda Cristina Mosini; Mariana Moysés‐Oliveira; Luana Nayara Gallego Adami; Sandra Doria Xavier; Bruna Pereira Marquezini; Anna Kloster; Bianca Balbueno; Claudia de Mello; Gustavo Moreira; Mônica L. Andersen published in Journal of Clinical Sleep Medicine (2024).
The aim i s to assess the impact of resistant focal epilepsy on the quality of patients' life. Materials and methods . Prospective, comparative, observational study conducted under conditions of real clinical practice. Inclusion criteria: age over 18 years; the presence of two or more epileptic seizures in history; a long history of treatment-resistant focal epileptic seizures; current AED therapy. Exclusion criteria: history of non-epileptic seizures of any etiology; inability to perform an MRI
Cannabis is used by an estimated 219 million adults globally (4.3% of the population) with a particularly high prevalence in North America (17.4% of the population).1 The 1961 UN Single Convention on Narcotic Drugs included cannabis with opioids and cocaine as a controlled substance whose use was prohibited, but policies have changed considerably in recent decades. Medical use of cannabis is now permitted in large parts of North and South America, Europe, and Oceania; although, patient access va
Cannabidiol (CBD) is the second-most common phytocannabinoid found in cannabis plants after tetrahydrocannabinol (THC). Unlike THC, no psychoactive effect has been demonstrated for CBD. Due to its effect on various neurotransmitter systems, it has been tried for the treatment of many physical and psychiatric diseases, considering its neuroprotective and anti-inflammatory properties. In this Editorial, the characteristics of CBD and its place in various psychiatric disorders will be briefly discu
These recommendations can be readily implemented clinically and provide a framework for future research. In patients receiving rTMS for a primary psychiatric disorder, assessment and management of co-occurring substance use is complex, requiring greater attention, standardization, and further study.
<b>Objectives:</b> Infantile and childhood epileptic encephalopathies are a group of severe epilepsies that begin within the first year of life and often portend increased morbidity. Many of them are genetically determined. The medical strategy for their management depends on the genetic cause. There are no facilities for genetic testing of children in Kazakhstan but we have a collection of data with already defined genes responsible for clinical presentations. <b>Methods:</b> We analyzed childr
Purpose Marijuana use has been increasing in the adolescent population. Our objective was to examine the prevalence of marijuana use among a sample of adolescents and young adults, determine an association with risk-taking behaviors, identify reported medical symptoms, and delineate common beliefs about marijuana use. Methods A questionnaire was administered to a sample of patients aged between 12 and 23 years old presenting to the emergency department of Penn State Hershey Medical Center, Hersh
Abstract Aim Medical cannabinoids are prescribed to children with cerebral palsy despite limited evidence. We aimed to assess the prescription practices of cannabinoids in children with cerebral palsy with a particular focus on indications and preparations used and how well cannabinoids are tolerated. Furthermore, we investigated how physicians acquire knowledge on cannabinoid medication. Methods We asked physicians with expertise in the care of children with CP on their prescription practices o
<b>Background:</b> T-type Ca<sup>2+</sup> channels (Ca<sub>v</sub>3) represent emerging therapeutic targets for a range of neurological disorders, including epilepsy and pain. To aid the development and optimisation of new therapeutics, there is a need to identify novel chemical entities which act at these ion channels. A number of synthetic cannabinoid receptor agonists (SCRAs) have been found to exhibit activity at T-type channels, suggesting that cannabinoids may provide convenient chemical s
Background: The medical marijuana industry and the sociopolitical atmosphere in which it exists have evolved tremendously over the past decade. However, little is known about the healthcare professionals' attitudes, perceptions, and behavior toward patient use of medical marijuana. In order to understand the legitimacy of medical cannabis in the future of palliative care, it is important to understand the beliefs and perceptions of healthcare professionals. Objectives: The purpose of this schola
Abstract Dravet syndrome (DS) is a rare childhood epilepsy disorder resulting in spontaneous, recurrent seizures (SRS) and behavioral co-morbidities. To facilitate the discovery and development of anti-seizure drugs for DS, the contract site of the NINDS Epilepsy Therapy Screening Program (ETSP) has continued to evaluate a mouse model of DS. Scn1a A1783V/WT mice exhibited increased hyperactivity, thigmotaxis, and deficits in nest-building behavior. Ex-vivo brain slice electrophysiology experimen
Canine thunderstorm aversion (CTA) is a significant challenge to pets, owners, and veterinarians. The objective of this research was to determine if traditional Chinese veterinary medicine (TCVM) treatment with acupuncture, Chinese herbal medicine, basic desensitization and counterconditioning (DSCC) with a behavior modification drug, could lessen the severity of CTA in dogs. A total of 23 dogs that exhibited behaviors typical of thunderstorm aversion were enrolled in the study. At study start,
Peer-reviewed industrial hemp research by Egon A. Ozer; Abdurrahman Keskin; Yusuf Huseyin Berrak; Fatma Cankara; Füsun Can; Yasemin Özdemir; Özlem Keskin; Attila Gürsoy; Hale Yapıcı Eser published in Discover Mental Health (2025).
Variants in the SYNGAP1 gene leading to decreased SynGAP protein expression are critical for the pathogenesis of mental retardation type 5 (MRD5). This study aims to explore the relationship between SYNGAP1 genotype and clinical phenotype through an expanded sample size, thereby enhancing the understanding of the specific mechanisms underlying MRD5. Data from previously published cases of patients with SYNGAP1 mutations were collected, and the relationship between genotype and clinical phenotype
Peer-reviewed industrial hemp research by Patrick Köck; Andrzej Badek; Maximilian Meyer; Arndt-Lukas Klaassen; Marc Walter; Jochen Kindler published in Child and Adolescent Psychiatry and Mental Health (2024).
• Instances of intrafamilial variability in CACNA1A variants have been identified, with differing clinical manifestations exhibited by affected family members. • Incomplete penetrance is a phenomenon that may occur, as neurodevelopmental or neuropsychiatric findings are not exhibited by some patients with CACNA1A variants.