Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
Stem cells play a critical role in human tissue regeneration and repair. In addition, cancer stem cells (CSCs), subpopulations of cancer cells sharing similar characteristics as normal stem cells, are responsible for tumor metastasis and resistance to chemo- and radiotherapy and to tumor relapse. Interestingly, all stem cells have cannabinoid receptors, such as cannabidiol (CBD), that perform biological functions. The aim of this systematic review was to analyze the effect of CBD on both somatic
Peer-reviewed industrial hemp research by Carlo Caffarelli; Francesca Santamaria; Ettore Piro; Simona Basilicata; Valeria Delle Cave; Marilena Cipullo; Sergio Bernasconi; Giovanni Corsello published in The Italian Journal of Pediatrics/Italian journal of pediatrics (2022).
These practical recommendations may be easily adapted for use in different countries, and should increase physicians' confidence in the initiation and monitoring of stiripentol treatment, thus facilitating effective management of patients with DS and improving clinical outcomes.
Cannabidiol (CBD), the main nonpsychoactive cannabinoid of cannabis, holds promise for nonaddictive treatment of pain. Although preclinical studies have been encouraging, well-controlled human trials have been largely unsuccessful. To investigate this dichotomy and better understand the actions of CBD, we used high-content calcium imaging with automated liquid handling and observed broad inhibition of neuronal activation by a host of ionotropic and metabotropic receptors, including transient rec
Abstract Background The attitudes and perceptions of medical practitioners towards medical cannabis is important to understand. A qualitative study was conducted to examine the attitudes and knowledge of medical doctors in South Africa towards medical cannabis. Methods Twenty medical doctors were recruited for online semi-structured interviews, which were guided by predefined themes including knowledge, legislation, willingness to prescribe, and potential risks. The data collected was analyzed u
New onset refractory status epilepticus (NORSE) is a diagnosis of exclusion for patients with refractory status epilepticus (RSE) without known epilepsy or identifiable seizure etiology. Patients fail to respond to conventional treatments, with seizures persisting for weeks or even months. When first line antiseizure medications (ASMs) fail, alternatives are pursued, including immunotherapy, cannabidiol, and ketogenic diet [1,2]. Electroconvulsive therapy (ECT) has been occasionally used for tre
This patient group demonstrated a reasonable response rate to an immunotherapy trial. These findings are surprising but support the consideration of an immunotherapy trial in patients with refractory epilepsy. Requirements for repeated courses of immunotherapy differed significantly between patients, and this is an area of interest for further research. The basis for response in this cohort remains unclear; in some cases, antiseizure medication changes may have contributed; however, without any
Abstract
 Cannabis has been used as a medicinal plant for thousands of years in Asia. Numerous physical, psychological, and emotional benefits have been attributed to cannabis since its first reported use in 2,600 BC in a Chinese pharmacopoeia. Recent years have seen a resurgence in interest in the therapeutic potential of compounds derived from these plants, mainly the non-psychoactive compound cannabidiol (CBD). In this way, we seek to evaluate, through this present study, what has been p
Silylation is a widely used derivatization technique for the gas chromatographic analysis of benzodiazepines, a class of psychoactive drugs commonly encountered in forensic and biological samples. This study investigated the optimal experimental conditions for the silylation of benzodiazepines using <i>N</i>,<i>O</i>-bis(trimethylsilyl)trifluoroacetamide containing 1% trimethylchlorosilane (BSTFA + 1% TMCS), a widely employed silylating agent. Ten structurally different benzodiazepines, includin
This study presented supporting evidence of the promising therapeutic effect of PER among patients with DS. PER can be considered one of the treatment options for this group of patients. However, several patients presented with unfavorable side effects that led to medication cessation. Future multicenter studies are required to explore further treatment options for patients with DS.
<b>Background/Objectives:</b> The main biologically active molecules of <i>Cannabis sativa</i> L. are cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). Both exert anticonvulsant effects when evaluated as single drugs, but their possible interaction as components of <i>C. sativa</i> extracts has been scarcely studied. For this reason, we evaluated CBD and THC, combined or not, in two seizure models in mice, using an improved vehicle formula. <b>Methods:</b> Firstly, acute seizures were induced
Peer-reviewed industrial hemp research by Obioha Ukaegbu; Jared G. Smith; David J. Hall; Thomas Frain; Cyrus Abbasian published in Journal of Cannabis Research (2021).
Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person-years adjusted for age and sex in women and men aged >60 years, respectively, compared to 18.1/100 000 in adults aged <60 years. In-hospital mortality associated with SE increases fourfold from the 3rd to 9th dec
Epilepsy is a central nervous system (neurological) disorder characterized by a bizarre feelings, sensations, and behaviors. Muscle spasms, convulsions, and loss of consciousness occasionally from epileptic seizures. Neuronal dependent on neurotransmitters in the central nervous system. In this review, we discussed epilepsy and its therapies, placing particular emphasis on some medicinal plants and their mechanism of action. The majority of herbal remedies that are both tested for anticonvulsant
Developmental Epileptic encephalopathies (DEEs) are severe neurological conditions where cognitive functions appear modulated by both seizure and interictal epileptiform activity. Cannabidiol (CBD) has been shown to be highly effective in the treatment of drug-resistant seizures in patients with DEEs. Along with its antiseizure effects, CBD demonstrated clinical beneficial effects in patients' quality of life, sleep and numerous adaptive behaviors. However, based on the available phase III studi
Epilepsy with myoclonic-atonic seizures (EMAS) is an early childhood epilepsy syndrome with an explosive onset of multiple seizure types in a previously healthy child. EMAS often evolves to a drug-resistant epileptic encephalopathy before a variable degree of remission around 3 years from onset. Highly purified cannabidiol (CBD, available in United States as Epidiolex®) has demonstrated efficacy and tolerability as an adjunct in medically refractory EMAS. We present two cases of medically refrac
The following disquisition investigates interpretations, insights, and inconsistencies causing conflicts, controversies, and consternation within the segment of the scientific community that studies the viability of treating physiological and psychological conditions through the administration of botanic cannabinoids. The intrinsic constructs and theories involved in this aspect of scientific inquiry are complex and convoluted, with deep-rooted biases dependent on the paradigm to which the resea
Abstract Behavioral addictions (BA) and substance use disorders (SUDs) share core features, including impaired control and craving, leading to significant personal and societal impacts. Previous research has identified the pre-supplementary motor area (pre-SMA) as a critical node in GD-related neurocircuitry, making it a potential target for interventions also in SUDs. Theta-burst stimulation (TBS) offers a non-invasive method to modulate pre-SMA activity. This study included 58 participants dia
Abstract Introduction Cannabis products have been used in the management of headaches in adults and may play a role in pediatric chronic pain. Canadian pediatricians report increasing use of cannabis for the management of chronic headaches, despite no well-controlled studies to inform its dosing, safety, and effectiveness. The aim of our clinical trial is to determine the dosing and safety of a Cannabidiol (CBD)-enriched Cannabis Herbal Extract (CHE) for the treatment of chronic headaches in ado
Impulsivity has been implicated as a factor in cannabis use and cannabis-related problems. However, impulsivity is a multi-faceted construct. Recent work in substance use has used the UPPS-P Impulsive Behavior Questionnaire (UPPS-P), which is designed to assess five facets of impulsivity. Research examining these facets of impulsivity and cannabis use characteristics is somewhat inconsistent, but generally has suggested that Sensation Seeking and Lack of Premeditation may be related to cannabis
Peer-reviewed industrial hemp research by Monsicha Ngampoopun; Charcrin Nabangchang; Piradee Suwanpakdee published in Journal of Cannabis Research (2022).