Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
The modified Delphi method is broadly used to evaluate debated topics. In this work, we sought the consensus on integrated and social care in epilepsy management. Both representatives of high-level epilepsy centers and patients' caregivers were directly involved.
Objetctive: Realize a systematic review on articles about cannabidiol (CBD) as an anxiolytic and antidepressant drug. Methodology: A systematic review in PubMed, Science Direct and PsycINFO databases taking into consideration articles published in English and Portuguese from 2008 to 2018 with animal experimentation. Results: Eleven articles with experimental studies on animals were included. All studies exhibited anxiolytic and antidepressant activities after CBD use. Conclusion: It was proven b
Epilepsy surgery may be a curative therapy for patients with drug-resistant epilepsies when focal lesions or foci are identified. Genetic testing is not yet routinely included in many presurgical evaluation programs although recent evidence support that finding a germline genetic mutation could help to better delineate the patient candidacy to surgery and provide valuable information on the expected surgery outcome. In this study, we report nine patients presenting drug-resistant focal epilepsy
Introdução. O canabidiol, fármaco derivado da Cannabis Sativa, tem sido usado em várias condições médicas, com resultados que têm sido discutidos. Aparentemente seus efeitos parecem melhores para quadros neurológicos, psiquiátricos, e quadros que envolvam dor importante, como em moléstias oncológicas. Método. Revisão de literatura sobre o uso do canabidiol e a sua relação com doenças neurológicas em geral. Foi consultada a base de dados PubMed. Além disso, foram lançadas as palavras "canabidiol"
Peer-reviewed industrial hemp research by Victoria Defelippe; Eva H. Brilstra; Willem M. Otte; Ghislaine J. M. W. van Thiel; J. Helen Cross; Finbar O’Callaghan; Valentina De Giorgis; Emilio Perucca; Kees P. J. Braun; Floor E. Jansen published in Orphanet Journal of Rare Diseases (2025).
While our study indicates the significance of genetic insights in adapting treatment approaches for pediatric epilepsy, it is important to temper our conclusions. The retrospective nature of our study confines our ability to definitively gauge the extent of precision medicine's utility. Our findings suggest the potential of genetic information to enhance epilepsy management, but the true impact of precision medicine can only be established through prospective investigations.
Peer-reviewed industrial hemp research by Jeremy H.M. Chan; Lourdes M. DelRosso; Chris Ruth; Joanna E. Wrede published in Journal of Clinical Sleep Medicine (2022).
Peer-reviewed industrial hemp research by Hirokazu Yamagishi; Hitoshi Osaka; Kazuhiro Muramatsu; Karin Kojima; Yukifumi Monden; Tadahiro Mitani; Yuta ASAKURA; K Wakae; Kohei Nagai; Toshihiro Tajima published in Scientific Reports (2024).
Peer-reviewed industrial hemp research by J. Scott Andrews; Drishti Shah; Alise Nacson; Tara Symonds; Sophie Hughes; Mahnaz Asgharnejad; Arturo Benitez; Lara Sams published in Journal of Patient-Reported Outcomes (2025).
Peer-reviewed industrial hemp research by Kelly Hollenack; J.D. Marshall published in PharmacoEconomics (2021).
This analysis demonstrates the importance of alerting cannabinoid users, particularly recreational cannabis users and those with a history of epilepsy, about seizure-associated risks. Moreover, educational information should be provided together with the prescription of licensed cannabinoids and medical cannabis.
Peer-reviewed industrial hemp research by Cristina Alonso; Alicia García‐Culebras; Valentina Satta; Inés Hernández-Fisac; A. Sierra; José Antonio Guimaré; Ignacio Lizasoaín; Javier Fernández‐Ruíz; Onintza Sagredo published in Brain Behavior & Immunity - Health (2025).
Although the current literature suggests a deleterious effect of recreational drugs on bone health and musculoskeletal disease, further research is warranted to evaluate the clinical effects of long-term substance use. The evaluation of such effects will aid in establishing appropriate pain regimens, as well as appropriate screening and treatment plans for recreational drug users.
This is the first report of a custom gene panel to identify genetic variants implicated in developmental and epileptic encephalopathy in the Tunisian population as well as the North African region (Tunisia, Egypt, Libya, Algeria, Morocco) with a diagnostic rate of 30%. This high-throughput sequencing panel has considerably improved the rate of positive diagnosis of developmental and epileptic encephalopathy in the Tunisian population, which was less than 15% using Sanger sequencing. The benefit
Griscelli syndrome (GS) is a rare syndrome characterized by hypopigmentation, immunodeficiency, and neurological features. The genes Ras-related protein (RAB27A) and Myosin-Va (MYO5A) are involved in this condition's pathogenesis. We present a GS type 1 (GS1) case with developmental delay, hypotonia, and refractory seizures despite multiple medications, which included clobazam, cannabinol, zonisamide, and a ketogenic diet. Lacosamide and levetiracetam were added to the treatment regimen, which d
However, it is recommended that more precise and comprehensive preclinical investigations be required to demonstrate the exact mechanism behind the anxiolytic effects and conduct clinical trials to determine efficacy and safety.
Epilepsy, a chronic neurological disorder affecting around 65 million people globally, is characterized by recurrent, unprovoked epileptic seizures. Psilocin, the active metabolite of psilocybin, a well-known psychedelic compound, has recently gained attention for its potential antidepressant and anxiolytic properties. This study aims to investigate the anticonvulsant effects of psilocin. The study utilizes behavioral seizure models and electrophysiological recordings in mice to assess the antic
Amaç: Kenevir antik çağlardan bugüne dek tedavi amaçlı kullanılmakta olan bir bitkidir. Her ne kadar kullanımı içerdiği psikoaktif bileşenler dolayısıyla sınırlandırılmış olsa da, kenevirin tıbbi yönüne dair araştırmalar literatürde oldukça yoğundur. Cannabis sativa L., içerdiği fitokannabinoidler ile endokannabinoid sistemde gen düzeyinde pek çok değişikliğe sebep olabilmektedir. Endokannabinoid sistemin pek çok patolojik durumda potansiyel bir terapötik hedef olabileceğine dair kanıtların derl
Peer-reviewed industrial hemp research by Jacopo Favaro; Alessandro Iodice; Margherita Nosadini; Francesca Asta; Irene Toldo; Claudio Ancona; Elena Cavaliere; Maria Federica Pelizza; Gianluca Casara; Lucio Parmeggiani published in Seizure (2024).
Antiseizure medications (ASMs) play a central role in seizure management, however, unpredictability in the response to treatment persists, even among patients with similar seizure manifestations and clinical backgrounds. An objective biomarker capable of reliably predicting the response to ASMs would profoundly impact epilepsy treatment. Presently, clinicians rely on a trial-and-error approach when selecting ASMs, a time-consuming process that can result in delays in receiving alternative non-ph
The appearance of SSW, even in seizure-free children, may herald the development of LGS in high-risk children. Further studies on its predictive value are warranted. Our findings also highlight use of recommended first-line therapy for infantile spasms as a potentially modifiable treatment gap in children who subsequently develop LGS.
Seizures occur in up to 59% of boys with creatine transporter deficiency (CTD). While seizure phenotypes have been previously described, electroencephalogram (EEG) findings have only been reported in several case reports. In this prospective observational study, we report seizure characteristics and EEG findings in combination with neurobehavioral and SLC6A8 pathogenic variants in twenty males with CTD. Eighteen study participants (SP) underwent video-EEG, and seven had follow-up EEG recordings.
Peer-reviewed industrial hemp research by Rebecca Strafella; Richard Wang; Marissa Petchpradub; Ariel Sacknovitz; Patricia E. McGoldrick; Steven M. Wolf published in Epilepsy & Behavior Reports (2024).
Our findings suggest that cannabidiol may benefit all adult patients with DRE, particularly those already receiving clobazam. Randomized controlled trials are warranted in off-label patients to validate these observational findings.
<p>Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder, characterised by deficits in verbal and non-verbal communication, social interaction and repetitive behaviours (APA, 2013). The aetiology of ASD is mostly unknown, with continued research identifying a multitude of genetic and non-genetic factors. However, it is the interaction between environmental factors and the genetic background of an individual which leads to the development of ASD. There is an urgent need for improv