Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
Tuberous sclerosis complex (TSC) is a rare multisystem genetic disorder characterized by benign tumor growth in multiple organs, including the brain, kidneys, heart, eyes, lungs, and skin. Pathogenesis stems from mutations in either the TSC1 or TSC2 gene, which encode the proteins hamartin and tuberin, respectively. These proteins form a complex that inhibits the mTOR pathway, a critical regulator of cell growth and proliferation. Disruption of the tuberin-hamartin complex leads to overactivatio
Complex genomic rearrangements (CGRs) are structural variants arising from two or more chromosomal breaks, which are challenging to characterize by conventional or molecular cytogenetic analysis (karyotype and FISH). The integrated approach of standard and genomic techniques, including optical genome mapping (OGM) and genome sequencing, is crucial for disclosing and characterizing cryptic chromosomal rearrangements at high resolutions. We report on a patient with a complex developmental and epil
Peer-reviewed industrial hemp research by Jonathon C. Arnold; Cassandra V. Occelli Hanbury-Brown; Lyndsey L. Anderson; Miguel A. Bedoya‐Pérez; Michael Udoh; Laura A. Sharman; Joel S. Raymond; Peter T. Doohan; Adam Ametovski; Iain S. McGregor published in Neuropsychopharmacology (2024).
Peer-reviewed industrial hemp research by Daniel San‐Juan; Axel Galindo Ruiz; Armando Baigts Arriola; Gerardo Quiñones Pesqueira; Giulio Ruffini; Carlos Trenado published in Seizure (2022).
In 1921, the classic ketogenic diet was created at the Mayo Clinic in Rochester, Minnesota to treat epilepsy in children and adults. Over a century later, it is a widely used, standard-of-care therapy for typically treatment-resistant epilepsy worldwide. There are currently five versions of ketogenic diet therapy that can be started either in or out of the hospital setting. It is overall effective in approximately half of children started, usually within a few months. Established indications for
The immune and nervous systems can be thought of as cognitive and plastic systems, since they are both involved in cognition/recognition processes and can be architecturally and functionally modified by experience, and such changes can influence each other's functioning. The immune system can affect nervous system function depending on the nature of the immune stimuli and the pro/anti-inflammatory responses they generate. Here we consider interactions between the immune and nervous systems in ho
Arguably significant progress and improvement in the medical and surgical treatments of seizures and epilepsy in children have occurred; however, there have been relatively fewer efforts in optimizing the care of lifestyle complications related to the disease state. Many patients have significant behavioral and mental health comorbidities, including ADHD (attention deficit hyperactivity disorder), which should be treated. After epilepsy surgery, only seizure freedom results in improved quality o
We describe the commissioning, publication, and contents of a report on legal aspects of memory. The report was the result of a unique collaboration between the Psychology and Law �Sections� of the British Academy that brought together the contributions of memory and legal experts from both inside and outside the Academy. The report briefly summarises psychological research on memory and is designed to be of practical value to busy legal and criminal justice professionals. Topics covered include
Este libro es una guía integral para profesionales de la salud en entornos de urgencias y trauma, enfocada en la evaluación y tratamiento de pacientes en situaciones críticas. Se destaca el enfoque ABCDE, un método sistemático que prioriza la estabilización de funciones vitales desde el primer contacto. Se profundiza en el manejo de la vía aérea y respiración, abordando técnicas cruciales como la intubación y ventilación mecánica. También se analizan emergencias cardiovasculares, proporcionando
Peer-reviewed industrial hemp research by Xinxiao Li; Shengnan Guo; Yangyang Sun; Jiangwei Ding; Chao Chen; Yuehui Wu; P. H. Li; Tao Sun; Xinjun Wang published in Journal of Translational Medicine (2024).
We demonstrated the relevance of the patients' psycho-social profile for decision-making in epilepsy surgery, particularly for patients' decisions. Thus, in addition to clinical-demographic variables, patients' individual psycho-social characteristics add to the understanding of surgical decision-making. From a clinical perspective, this calls for individually tailored counseling to assist patients in finding the optimal treatment option.
The cannabis plant is the most used federally illegal drug in the United States and is widely used by adolescents. Cannabis has complex effects on the body and mind. All health professionals who take care of adolescents with cystic fibrosis (CF) should be aware of the factors impacting cannabis use in CF. Given limited evidence regarding the benefits of cannabis and the significant risks, clinicians have the responsibility to identify risk of cannabis use early, counsel patients about the risks,
CDKL5 deficiency disorder (CDD) is a complex of clinical symptoms resulting from the presence of non-functional or absent CDKL5 protein, a serine–threonine kinase involved in neural maturation and synaptogenesis [...]
Introduction. The anticonvulsant drug range expansion, the change in the treatment strategies, and person-oriented approach to choosing the optimal drug dictates the need for marketing research to update and systematize data on the state of the national pharmaceutical market of anticonvulsants. Carrying out a marketing analysis of the antiepileptic drugs (AEDs) market, including determining the market situation and the qualitative characteristics of this group of drugs, is necessary to prescribe
Cannabis-derived products such as cannabidiol are now increasingly prescribed for different refractory childhood epilepsy syndromes. This raises the question about cognitive and behavioural safety of chronic use in young children. As there are no long-term data to answer this question, we can look for indirect evidence. In this short review, we focus on three lines of research: data obtained from the randomised controlled trials with cannabidiol, data on the consequences of prenatal cannabis exp
Dravet syndrome (DS) is a genetic disorder caused by a deficit in the Nav1.1 channel, leading to drug-resistant epilepsy. The Nav1.1 channel plays a crucial role in microglial cell activation, and microglia are recognized as key mediators of seizures. In this study, we explored the role of microglia in DS-related epileptogenesis using a knock-in mouse model (<i>Scn1a<sup>E1099X/+</sup></i>) that mimics a subset of DS patients. In these DS mice, we observed a significant downregulation of the Nav
<b>Background</b>: <i>Gardnerella vaginalis</i> is a natural inhabitant of the vagina, but when an imbalance occurs in the vaginal microbiota, this bacterium can cause vaginosis, a condition that must be treated when symptomatic and prior to a gynecological intervention. Cannabidiol (CBD) is an anti-inflammatory compound that also has antibacterial activities against several Gram-positive and certain Gram-negative bacteria. <b>Objectives</b>: Since <i>G. vaginalis</i> is an opportunistic pathoge
By analyzing traditional deep learning multimode retrieval methods, an optimized multimode retrieval model based on convolutional neural network is established. This article proposes an innovative semi-supervised social network user portrait analysis model (UPAM) based on user portrait model, which integrates users' social information and some known user attribute information (such as educational background and residence) into a unified topic model framework. Finally, a semi-supervised user port
Cannabidiol (CBD <b>1</b>) is a nonpsychotic cannabinoid-based drug approved by the U.S. FDA for treating refractory epilepsy, namely, Lennox-Gastaut and Dravet syndrome. However, its low aqueous solubility and oral bioavailability are compensated by administering high doses, and there is an increased demand for conjugates with improved properties. In this direction, the present work is focused on synthesizing CBD-based prodrugs to address the issue of poor solubility and oral bioavailability. S
These findings support the role of <i>SCN1A</i>-dsAS in the suppression of <i>SCN1A</i> mRNA generation. Considering the haploinsufficiency in genetic <i>SCN1A</i> related DS, <i>SCN1A</i>-dsAS is an interesting target candidate for the development of ASOs (AntagoNATs) based precision medicine therapeutic approaches aiming to enhance <i>SCN1A</i> expression in DS.
Febrile-infection-related epilepsy syndrome survivors may regain vital functions and mobility but experience a significant loss of independence and participation due to recurring seizures, structural brain damage and neurocognitive decline. Minimization of disastrous outcomes through the systematic evaluation of rescue therapies within a network of specialized centres is crucial.
This case describes various treatment strategies, constraints, and device limitations when using ECT for the treatment of SE. With wide variability in efficacy rates of ECT in the treatment of SE in the literature, successful and unsuccessful cases offer information on optimizing ECT total charge dose and parameters that yielded success. This case demonstrates an instance of ECT inefficacy in the treatment of SRSE. Here, we discuss the rationale behind the various ECT settings that were selected