Hemp Research — Page 85

Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels (2023)

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed vi

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels (2021)

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide con

Neuropathic Pain: Mechanism-Based Therapeutics (2020)

Neuropathic pain (NeP) can result from sources as varied as nerve compression, channelopathies, autoimmune disease, and incision. By identifying the neurobiological changes that underlie the pain state, it will be clinically possible to exploit mechanism-based therapeutics for maximum analgesic effect as diagnostic accuracy is optimized. Obtaining sufficient knowledge regarding the neuroadaptive alterations that occur in a particular NeP state will result in improved patient analgesia and a mech

<p>Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases</p> (2020)

<b>Salvia miltiorrhiza</b>: (Danshen) is a significant (traditional Chinese medication) natural remedy, enhancing blood circulation and clear blood stasis. In this view, it is widely used against several heart diseases, eg, cardiomyopathy, arrhythmia, and congenital heart defects. Tanshinone IIA (tan-IIA) is the main fat-soluble component of <i>Salvia miltiorrhiza</i>. Modern pharmacological study shows that tan-IIA has anti-inflammatory and anti-oxidant activities. Tan-IIA induces remarkable ca

An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L. (2023)

<i>Calendula officinalis</i> Linn. (CO) is a popular medicinal plant from the plant kingdom's Asteraceae family that has been used for millennia. This plant contains flavonoids, triterpenoids, glycosides, saponins, carotenoids, volatile oil, amino acids, steroids, sterols, and quinines. These chemical constituents confer multifaceted biological effects such as anti-inflammatory, anti-cancer, antihelminthic, antidiabetes, wound healing, hepatoprotective, and antioxidant activities. Additionally,

Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action (2020)

Acetaminophen is one of the most commonly used analgesic agents for treating acute and chronic pain. However, its metabolism is complex, and its analgesic mechanisms have not been completely understood. Previously, it was believed that acetaminophen induces analgesia by inhibiting cyclooxygenase enzymes; however, it has been considered recently that the main analgesic mechanism of acetaminophen is its metabolization to <i>N</i>-acylphenolamine (AM404), which then acts on the transient receptor p

Selective Targeting of TNF Receptors as a Novel Therapeutic Approach (2020)

Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-inflammatory effects, drugs that neutralize TNF were developed and are clinically used to treat inflammatory and autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease and psoriasis. However, despite their clinical success the use of anti-TNF drugs is limited, in part due to unwanted, severe side effects and in some diseases its use even is contraindicative. With gaining knowledge about

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels (2019)

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors (2021)

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide con

Cannabinoid Ligands Targeting TRP Channels (2019)

Transient receptor potential (TRP) channels are a group of membrane proteins involved in the transduction of a plethora of chemical and physical stimuli. These channels modulate ion entry, mediating a variety of neural signaling processes implicated in the sensation of temperature, pressure, and pH, as well as smell, taste, vision, and pain perception. Many diseases involve TRP channel dysfunction, including neuropathic pain, inflammation, and respiratory disorders. In the pursuit of new treatme

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors (2019)

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400

Biosocial Profile of Patients with Age-Related Macular Degeneration (AMD) Undergoing Ranibizumab (2024)

The Fourth Brazilian Congress of Pharmacotherapy and Clinical Pharmacy showcases Brazil's role within the vibrant and evolving community of pharmacotherapy and clinical pharmacy in Latin America. This volume offers a window into Brazil's ongoing contributions as part of a collective Latin American effort, presenting a comprehensive collection of scientific investigations and documented clinical experience reports that address important healthcare challenges. Containing hundreds of peer-reviewed

Alzheimer's disease and inequality: profile of hospital costs, mortality, and length of stay across different educational levels (2025)

Background: Socioeconomic factors such as educational level and income significantly influence hospital outcomes in Alzheimer’s disease (AD). Understanding the impact of social inequality and education is essential to guide equitable care strategies. Objective: To analyze hospital costs, mortality, and length of stay related to AD across different educational levels, highlighting social disparities in hospital outcomes in Brazil. Methods: This ecological, cross-sectional epidemiological study us

USE OF CANNABIDIOL (CBD) IN GENERALIZED ANXIETY DISORDER: CURRENT EVIDENCE AND THERAPEUTIC PERSPECTIVES (2025)

This study aims to review the current scientific evidence regarding the use of cannabidiol (CBD) in the treatment of Generalized Anxiety Disorder (GAD). CBD, one of the main phytocannabinoids derived from Cannabis sativa, exhibits a consistent anxiolytic potential without inducing significant psychoactive effects, distinguishing it from tetrahydrocannabinol (THC). Preclinical and clinical evidence indicates that CBD modulates the endocannabinoid system and serotonergic receptors, promoting anxie

Subjective cognitive decline and cognitive performance among older adults (2025)

Background: Subjective Cognitive Decline (SCD) may represent a preclinical stage of mild cognitive impairment, but its prevalence is underexplored in developing countries, and standardized assessment tools are lacking. Objective: To examine the relationship among SCD, cognitive performance, and mood variables in older adults. Method: A total of 207 older adults from community centers and retiree associations were assessed using the Cognitive Function Instrument (CFI) for SCD, the Addenbrooke’s C

Neuropsychological Functioning Among Individuals with Marijuana Use and Posttraumatic Stress Symptoms (2020)

The recent legalization of marijuana in many states across the nation has led to an increase in access to marijuana recreationally and as a prescription medication for the treatment of posttraumatic stress disorder (PTSD) symptoms (Bonn-Miller et al., 2014).Marijuana use has shown both positive and negative effects on PTSD symptomatology (Greer et al., 2014;Wilkinson et al., 2015).Separately, PTSD and marijuana use are associated with poorer neuropsychological functioning (e.g., Johnsen & Asbjor

Immersed memories: the potential of virtual reality in Alzheimer’s disease (2025)

The use of virtual reality (VR) in healthcare has garnered growing interest as a complementary strategy in the care of individuals with dementia. By enabling more realistic and engaging experiences, VR emerges as an innovative alternative to traditional cognitive stimulation approaches. Despite its potential, significant gaps remain regarding its clinical applicability, particularly among older adults diagnosed with Alzheimer’s disease (AD). This study aimed to synthesize, through a systematic r

Profiling underdiagnosed dementia in older Brazilian population: Insights from the ELSI-Brasil study (2025)

Introduction: Dementia underdiagnosis is a public health challenge worldwide. Herein, we aimed to estimate the prevalence of underdiagnosed dementia and identify associated sociodemographic factors. Methods: Data from the ELSI-Brasil Study (Wave 1, 2015–2016) were used. Individuals were classified with dementia based on a global cognitive composite score (including orientation, fluency, and memory recall scores) and functional impairment, defined as dependency in at least one of four instrumenta

The eukaryotic elongation factor 2 kinase participates in microglial activation and amyloid clearance in Alzheimer’s disease (2025)

Increasing evidence suggests important roles for soluble Aβ oligomers (AβOs) and, more recently, tau oligomers (TauOs) in the pathogenesis of Alzheimer's disease (AD). Although several cellular events underlying AD pathophysiology are well established, little is known about the mechanisms that lead to the loss of microglial homeostasis, which represents a key factor in disease progression. We and others have previously demonstrated that global protein synthesis is attenuated, and phosphorylation

Characteristics of Patients Admitted to the Medical Ward with a Positive Urine Test for Cannabis: A Medical Center Experience (2025)

Introduction: Cannabis (marijuana) use (medical) and abuse is becoming more and more common practice among different age groups in Israel. There is nearly no data regarding patients admitted to the medical ward with a positive urine test for marijuana. Research Methods: All the patients admitted to the medical ward at Laniado Hospital during the previous 3 years with positive urine test for marijuana were identified. Demographic, clinical and Lab parameters were documented. Patients were divided