Peer-reviewed industrial hemp research papers, sorted by publication date. Browse the latest findings on hemp cultivation, processing, materials science, biomedical applications, and regulatory science from PubMed, OpenAlex, and other indexed sources.
RNA-binding proteins (RBPs) serve as key regulators of hepatocellular carcinoma (HCC); however, the specific mechanisms by which RBPs function in this context require clarification. Here, we identify an RBP, ATXN2L (ataxin 2-like), that is significantly upregulated in HCC tissues and correlates with a poor prognosis. Knockdown of ATXN2L in HCC cells or knockout of Atxn2l in mice suppresses HCC progression. Mechanistically, enhanced liquid-liquid phase separation (LLPS) activity of ATXN2L results
Further research should determine the long-term efficacy, safety, and appropriate dosages of enriched CBD oil extracts in treating specific ADs rather than broad and unspecified anxiety symptoms. The state of the art of CBMFs for ADs should be warranted by future randomized controlled trials. The next stage for cannabis research should be focused in performing head-to-head trials comparing enriched CBD extracts or capsules versus first-line treatments proven to be effective in ADs.
Neurological disorders (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), epilepsy, despondency, and dementia have been evidenced as a rising concern among diverse geographical regions. Brain-related diseases are currently the main concern because they increase mortality and morbidity in the elderly. Regardless of the continual efforts by modern scientists to develop a promising pharmacological or surgical management, the outcome has not been satisfactory. Also, due to synthetic d
The antioxidant effects of SBE likely involve multi-pathway and multi-target mechanisms, consistent with the combinatorial properties of its herbs constituents. These findings lays a foundation for subsequent research. Video Abstract.
Peer-reviewed industrial hemp research by Tiange Deng; Yang Xue; Yiming Wang; Xiang Guo; Zhen Ma; Hongzhi Zhou; Zhicheng Yang; Zhengwu Peng; Xiangxiang Hu; Ning Li published in BMC Oral Health (2025).
Unprescribed cannabis use is common in patients with MS in Italy, with observed prevalence seemingly superior to the general population, often intended for medical use and without the disclosure to the treating physician, although with potential clinical benefits.
<title>Abstract</title> The nervous system is a sensitive target of electromagnetic radiation. Chronic microwave exposure could induce cognitive deficit and 5-HT system was involved in it. Genetic polymorphisms lead to individual differences. In this study, we evaluated whether the single nucleotide polymorphism rs198585630 of 5-HT<sub>1A</sub> receptor were associated with cognitive alterations of rats after microwave exposure. The transcriptional activity of 5-HT<sub>1A</sub> receptor promoter
Introdução: O transtorno de ansiedade é uma condição que pode afetar tanto o aspecto mental quanto físico, levando a sintomas como pensamentos acelerados, dificuldades de concentração, insônia, sudorese excessiva, ataques de pânico, além de poder contribuir para o desenvolvimento de várias outras doenças. Sob essa ótica, o uso de plantas medicinais com fins terapêuticos, seja para tratar, curar ou prevenir enfermidades, têm se tornado cada vez mais comum. Objetivo: Realizar um levantamento bibli
Genetic variability influences psychological vulnerability in fibromyalgia. Specific variants were associated with key psychological traits: BDNF rs6265 with pain catastrophising, OPRM1 rs1799971 with anxiety, and MAOA rs1137070 with depressive symptoms. These findings reveal an interplay between genetic and psychological factors that may guide more personalised strategies for managing fibromyalgia.
Cyclic vomiting syndrome (CVS) is a frequently disabling condition defined by severe, discrete, stereotypical episodes of nausea and vomiting. In our previous report [1], a candidate gene list was evaluated in a group of 80 unrelated participants with CVS with extensive genetic sequencing (whole exome/genome). Twenty-two good candidate genes for CVS association were identified, from which a cellular model of aberrant cation transport and energy metabolism was proposed. Herein, we present additio
Introduction:The cannabis plant, whose best-known species include sativa, indica, and rhododendris has been a subject of controversy and debate.It has also been the subject of intense political debates, with proponents of legalization arguing that it should be decriminalized and regulated, while opponents argue that it is a dangerous drug that should remain illegal.One of the most significant arguments in favor of cannabis legalization is that it could reduce drug addiction by providing a safer
Major depressive disorder arises from complex interactions between genetic variation, environmental influences, and receptor-mediated signaling that regulate mood, cognition, and stress resilience. This review synthesizes recent empirical evidence examining how genetic and epigenetic variation intersect with receptor function, binding, and expression to shape depressive phenotypes and treatment outcomes. Findings are organized into ten interconnected biochemical domains: monoaminergic, glutamate
NanoBEO represents a public-worth innovation in this neglected area, marking a significant advancement in the history of dementia, moving from academic research to product development.
Colorado was the first state to legalize recreational cannabis in the United States. In November 2012, the inaugural state passed Colorado Amendment 64, which legalized the manufacturing, commercial sale, and use of recreational cannabis for adults aged 21 years or older. Research has suggested an upward trend in the number of cannabis-related adverse events in Colorado since legalization, possibly because of the increased availability and use of the drug. 2 This was further supported by an incr
Cannabis, the most widely used illicit substance globally, has seen a significant increase in usage, driven by the growth of the cannabis industry and evolving public opinion on potential risks. Understanding the differential effects of cannabis on males and females is becoming increasingly significant. This paper aims to investigate the sex differences in cannabis use, including patterns, motivations, and physiological responses, and their impact on health and well-being. Usage patterns exhibit
Background: Endometriosis is a gynecological, multifactorial condition that affects women’s life quality, especially due to the pain inherent to it. Pain is caused by physical and psychological aspects; therefore, several factors must be analyzed, aiming to treat the whole. Conventional, drug or surgical treatments are the most used; however, the search for alternative therapeutic methods is growing. Objective: To analyze the approach to pain in women with endometriosis, seeking a better underst
Our study provides the first evidence that eCBs may contribute to individual differences in sensitivity to alcohol's reward-related mechanisms by influencing subjective experience, offering insight into the potential role of eCBs in the processes underlying harmful alcohol use.
Feder et al had previously found a significant and quick decrease in PTSD symptoms after a single dose of IV ketamine had. This is the first RCT to examine the effectiveness and safety of repeated IV ketamine infusions for the treatment of persistent PTSD.
Epilepsy is a highly prevalent condition and affects about 50-65 million people worldwide with great impact on health and quality of life, including medical and social aspects. Electroencephalography (EEG) represents the main diagnostic approach to evaluate patients with epilepsy. EEG techniques have achieved significant improvement over the years and keep evolving to meet increasing demands such as higher accuracy, innovation and better quality and technique to enable improved diagnosis and tre
The search and development of new therapeutic agents from medicinal plants to alleviate anxiety is well justified due to the increasing cases of anxiety disorder and lack of effective treatment. Moringa oleifera has been used traditionally to treat anxiety. However, there is still lack of understanding on the mechanism for its anxiolytic effect. The purpose of this study was to investigate the anxiolytic effects and the mechanism of ethanolic extracts of the leaves of M. oleifera (MOLE) by obser
Background: The beneficial effect of transcranial direct current stimulation (tDCS) on substance use disorders, achieved by reducing craving, impulsivity, and risk-taking behavior, can be considered an effective therapeutic approach. Transcranial direct current stimulation can be considered an effective therapeutic approach for reducing cannabis craving, improving levels of depression, and enhancing working memory in cannabis users. Objectives: This study investigated the effectiveness of tDCS a
This practice-based evidence demonstrated that the multidimensional approach to care provided by the Musicians' Clinics of Canada benefited all groups at six months. Medical cannabis significantly reduced pain intensity in new users of medical cannabis with PRMD, and all groups saw improvements in pain interference. In keeping with prior studies, medical cannabis seems to be effective at reducing perceptions of pain, including for PRMD. CBD/THC dosing was within guideline recommendations, and no
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social communication and restricted or repetitive behavior and interests. Psychic distress is common among individuals with ASD, especially in its milder form (level 1), with anxiety and depression being the most common types. Recent research has identified neuroinflammation and gut dysbiosis as potential neurobiological mechanisms underlying ASD. Palmitoylethanolamide (PEA), an endocannabinoid (eC
Peer-reviewed industrial hemp research by Solène Wallez; Isabelle Kousignian; Irwin Hecker; Selma Faten Rezag Bara; Astrid Juhl Andersen; Maria Melchior; Jean‐Sébastien Cadwallader; Murielle Mary‐Krause published in Journal of Cannabis Research (2024).